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EC number: 217-703-5 | CAS number: 1934-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Acceptable for assessment but without detailed documentation. Study report meets basic scient ific p rinciples. Study was conducted prior to GLP and OECD guideline implementation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Department of Transportation (DOT) regulations
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: METHOD FOR PRIMARY IRRITATION DEPARTMENT OF TRANSPORTATION ACT
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- study performed prior to GLP implementation
Test material
- Reference substance name:
- Sodium dicyanoamide
- EC Number:
- 217-703-5
- EC Name:
- Sodium dicyanoamide
- Cas Number:
- 1934-75-4
- Molecular formula:
- C2HN3.Na
- IUPAC Name:
- sodium dicyanamide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino rabbits
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent skin
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 4 (initial reading directly after patch removal), 24 and 48 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 1.5 x 1.5 inch (3.8 x 3.8 cm)
- Type of wrap if used: clear plastic trunk bands
REMOVAL OF TEST SUBSTANCE
- Washing (if done): following initial reading
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 4, 24, 48 hours
SCORING SYSTEM:
- Method of calculation: The primary irritation index was calculated by adding the values for erythema or eschar formation, and edema at 4, 24 and 48 hours on intact and abraded skin (12 values) and dividing by six to obtain an individual score on each rabbit.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- animal: #1 - #6
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- animal: #1 - #6
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The initial scores directly following the 4 hours exposure were 0 in all animals (intact skin).
Judgment is based on erythema and edema calculated as mean scores for each animal following grading at 24 and 48 hours after removal of the test material, in consideration of reversibility.
The following mean scores were calculated: erythema 0/0/0 and edema 0/0/0. - Other effects:
- not reported
Any other information on results incl. tables
Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
direct following patch removal |
0/0/0 |
0/0/0 |
24 h |
0/0/0 |
0/0/0 |
48 h |
0/0/0 |
0/0/0 |
72 h |
-/-/- |
-/-/- |
Average 24h, 48h, |
0/0/0 |
0/0/0 |
Reversibility*) |
||
Average time (unit) for reversion |
|
|
*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Judgment is based on erythema and edema calculated as mean scores for each animal following grading at 24 and 48 hours after removal of the test material, in consideration of reversibility.
The following mean scores were calculated: erythema 0/0/0 and edema 0/0/0. - Executive summary:
In a primary dermal irritation study according to Department of Transportation (DOT) regulations, 6 albino rabbits of unknown sex were dermally exposed to 0.5 g of sodium dicyanoamide (100% a.i) to approx. 8 cm² skin surface (intact skin). The animals were subsequently exposed for 4 hours. Following initial reading, the test sites were washed.
The means of the erythema and edema evaluations at 4 (initial reading), 24 and 48 hours for the six animals after a four-hour exposure were 0 (erythema) and 0 (edema).
In this study, sodium dicyanoamide is classified as not irritating to rabbit skin according the criteria of CLP, EU GHS (Regulation (EC) No 1272/2008).
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