Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 904-551-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draize, (Appraisal of the safety of chemicals in Foods, Drugs, and Cosmetics, published in 1959 by the association of food and drugs officials of the united states, P. 52)
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
- EC Number:
- 904-551-6
- Molecular formula:
- C16H24O
- IUPAC Name:
- Reaction mass of 1-(2,6,6-trimethylcyclohex-2-en-1-yl)hepta-1,6-dien-3-one and 1-(2,6,6-trimethylcyclohex-1-en-1-yl)hepta-1,6-dien-3-one
- Test material form:
- liquid
1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 47 subjects started the program of which 40 subjects completed the program.
- Sex: 12 males and 28 females
- Age: 6 (16-20 years), 8 (21-30 years), 11 (31-40 years), 7 (41-50 years) 7 (51-60 years), 1 (60 years). - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: patch test
ADMINISTRATION
- Type of application: Early in the test program a large number of subjects was similary tested with 95% ethanol on similar test patches, and a smaller number was tested with similar samples and with alcohol applied under closed patches. The results of these experiments, demonstrated that closed patch exposure caused frequent strong reactions, even to alcohol alone, and that alcohol on the semi-open test patch adopted caused essentially no irritation.
- Description of patch: The test patch was a one-inch square of Webril (absorbent woven cotton facric) affixed to the centre of a 1 X 3 - inch strip of adhesive elastic bandage material. The test bandages were specially prepared by Duke Laboratories, Inc.
- Vehicle / solvent: ethanol
- Concentrations: 6.25%
- Volume applied: 0.5 mL
- Testing/scoring schedule: Six to nine different samples were were tested simultaneously on each group of subjects, and the order in which they were applied was rotated from one subject to the next. The subjects removed the bandages 24 hours after application. the basic schedule for the large number of tests in the program of which this is a part compried a series of nine 24-hour exposures on a Monday-Wednesday-Friday sequence for three successive weeks, the reaction to each exposure being scored at the session following and the reaction to the ninth application on monday of the fourth week. The test patch was applied to the same site each time, unless reaction to sample or tape adhesive rendered this inadvisable, in which case the test patch was either omitted or applied to a fresh site. On monday of the sixth week a challenge patch was applied to a site not previously exposed, and removed after 24 hours. Reactions to the challenge were scored on Wednesday and Friday of this week. Minor departures from this scedule were occasionally necessitated and were recorded.
EXAMINATIONS
- Grading/Scoring system: 0: No evidence of irritation, 1: slight erythema, 2: marked erythema, 3: erythema and papules, E: erythema and edema, 4: Very strong edema and/or papules, 5: vesicular eruption, 6: grade E or stronger reaction extending well beyond area of contact.
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
None of the 40 subjects tested was sensitized by the sample.
OTHER RESULTS:
Subjects 11, 17, 43, and 58 were tested with closed patches for the first three applications, with the regular semi-open patches thereafter. Subject 17 exhibited strongly edematous reactions to the adhesive tape of the bandage after the fifth application and was therefore excused from further participation.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test 6.25% test substance was not sensitising.
- Executive summary:
A HRIPT test was performed with 6.25% test substance in ethanol. 40 volunteers finished the study and were exposed to 1 mL solution mainly under semi-occlusive conditions. The subjects removed the bandages 24 hours after application. The basic schedule for the large number of tests in the program of which this is a part compried a series of nine 24-hour exposures on a Monday-Wednesday-Friday sequence for three successive weeks, the reaction to each exposure being scored at the session following and the reaction to the ninth application on Monday of the fourth week. The test patch was applied to the same site each time, unless reaction to sample or tape adhesive rendered this inadvisable, in which case the test patch was either omitted or applied to a fresh site. On Monday of the sixth week a challenge patch was applied to a site not previously exposed, and removed after 24 hours. Reactions to the challenge were scored on Wednesday and Friday of this week. Minor departures from this schedule were occasionally necessitated and were recorded. None of the 40 subjects tested was sensitized by the sample. Under the conditions of the test 6.25% test substance was not sensitising.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.