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EC number: 812-244-2 | CAS number: 957209-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.024 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No immobilization in exposed organisms
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No immobilization in exposed organisms
- Conclusions:
- Novec 7700 is estimated to have no effect on Daphnia magna at its limit of water solubility (OECD 202).
- Executive summary:
Novec 7700 short-term toxicity to aquatic invertebrates is assessed by readacross from Novec 7800. Toxicity of Novec 7800 to Daphnia magna under semistatic conditions was examined in a limit test according to OECD 202 guidelines. Water-accomodated fractions were made at a loading rate of ca. 100 mg/L with renewal at 24 hours. Geometric mean concentration was 0.0244 mg/L. No biological effects were observed. The EC50 based on measured concentration was >0.0244 mg/L, with an EL50 of >100 mg/L based on nominal loading rate. As explained in the justification for type of information, the structural difference between Novec 7700 and Novec 7800 is unlikely to lead to a difference in short-term toxicity to aquatic invertebrates.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May - 1 June 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: Lot number 1
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, darkness
- Stability under test conditions: Stable - Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Samples were taken before and after replacement. Samples for the initial and 24-hour replacement time points were taken from the stock solution used to fill the test vessels. Samples from the 24-h and 48-h spent test solutions were taken after pooling all test solutions for that time point.
- Sample storage conditions before analysis: Samples analyzed immediately - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A water-soluble fraction was prepared at a loading rate of ca. 100 mg/L. After stirring 48 hours at 23 °C in a closed flask with no headspace, the suspension was allowed to settle for 2 hours and liquid drawn from the middle of the flask. The withdrawn liquid was divided into the test vessels, and the test vessels were immediately covered to avoid headspace.
- Controls: Untreated test medium
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): None, test solutions were clear and colorless at start of test and before and after renewal. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain/clone: Clone A, originally from University of Sheffield, UK
- Source: Internal laboratory subculture
- Age of parental stock: 30 days, bred for at least 14 days.
- Breeding conditions same as test conditions: Yes
- Feeding during test: No
- Age at test initiation: < 24 hrs
- Acclimation period: None - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 41.9 mg CaCo3/L
- Test temperature:
- 19.8 - 20.1 °C
- pH:
- 7.7 - 7.8
- Dissolved oxygen:
- 8.3 - 8.4 mg/L
- Salinity:
- Not applicable
- Conductivity:
- 18.3 mS/m
- Nominal and measured concentrations:
- Nominal: Negative control and 100 mg/L loading rate
Measured: <0.00279 mg/L, 0.0244 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass petri dish, 8.5 cm diameter, 5 cm depth, filled to eliminate headspace. Volume ca. 320 mL
- Type (delete if not applicable): Closed
- Aeration: None
- Renewal rate of test solution: Once at 24 hrs
- No. of organisms per vessel: Five
- No. of vessels per concentration: Four
- No. of vessels per control (replicates): Four
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated municipal tap water, see Attachment 1 for details
- Total organic carbon: 0.2 mg/L
- Particulate matter: <1 mg/L suspended matter
- Metals: Ca, 11.5 mg/L; Mg, 3.2 mg/L; Al, 0.033 mg/L, Na 14.3 mg/L, K, 3.7 mg/L. Others below limit of determination
- Pesticides: below limit of determination
- Chlorine: Free chlorine below limit of determination
- Alkalinity: 35 mg/L
- Ca/mg ratio: 3.59 (mass basis)
- Culture medium different from test medium: No
- Intervals of water quality measurement: Most recent analysis five months before test
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light:8 hours dark
EFFECT PARAMETERS MEASURED: Mobility at 24 and 48 hours
RANGE-FINDING STUDY
- Test concentrations: Negative control and 100 mg/L loading rate.
- Results used to determine the conditions for the definitive study: No toxicity observed. - Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.024 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No immobilization in exposed organisms
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: No immobilization in exposed organisms
- Details on results:
- - Abnormal responses in exposed organisms: None:
- Mortality of control: None
- Other adverse effects control: None
- Abnormal responses: None
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: None
- Effect concentrations exceeding solubility of substance in test medium: Yes - Results with reference substance (positive control):
- A 48-hour acute immobilization test of K2Cr2O7 with the test organisms was conducted 50 days prior to the current study to confirm the reproducibility of the test conditions. The 48-hour EC50 of K2Cr2O7 was 0.270 mg/L. This value was within the normal range in this laboratory [mean ± SD: 0.236 ± 0.057 mg/L (n=58)].
- Validity criteria fulfilled:
- yes
- Remarks:
- <10% of controls immobilized or trapped at water surface (0%), DO >60% saturation (no significant decline)
- Conclusions:
- Novec 7800 has no effect on D. magna at its limit of water solubility (OECD 202)
- Executive summary:
Toxicity of Novec 7800 to Daphnia magna under semistatic conditions was examined in a limit test according to OECD 202 guidelines. Water-accomodated fractions were made at a loading rate of ca. 100 mg/L with renewal at 24 hours. Geometric mean concentration was 0.0244 mg/L. No biological effects were observed. The EC50 based on measured concentration was >0.0244 mg/L, with an EL50 of >100 mg/L based on nominal loading rate.
The test was conducted according to an internationally accepted test guideline under GLP. Considerable test substance was lost during the experiment; however, as a volatile and insoluble material some losses are considered unavoidable. The study is deemed reliable with restriction and suitable for use in Risk Assessment, Classification & Labeling, and PBT Analysis.
Referenceopen allclose all
Table 1, Concentration of Novec 7800, dissolved (measured after sample was allowed to rest 24 hours before analysis)
Nominal concentration (mg/L) |
Measured concentration (mg/L) |
||||
Initial |
24 h, spent |
24 h, renewal |
48 h |
Geometric mean |
|
0 mg/L (Control) |
<0.00279 |
<0.00279 |
<0.00279 |
<0.00279 |
─ |
100 mg/L |
0.0234 |
0.0105 (44.7%) |
0.0494 |
0.0294 (59.5%) |
0.0244 |
Table 2, Concentration of Novec 7800, suspended (measured immediately after sample was collected)
Nominal concentration (mg/L) |
Measured concentration (mg/L) |
||||
Initial |
24 h, spent |
24 h, renewal |
48 h |
Geometric mean |
|
0 mg/L (Control) |
<0.00279 |
<0.00279 |
<0.00279 |
<0.00279 |
─ |
100 mg/L |
0.0772 |
0.0156 |
0.0935 |
0.0398 |
0.0460 |
Results were reported based on the "dissolved" concentration.
Description of key information
Novec 7700 is estimated to have no effect on Daphnia magna at its limit of water solubility (OECD202)
Key value for chemical safety assessment
Additional information
Novec 7700 short-term toxicity to aquatic invertebrates is assessed by readacross from Novec 7800. Toxicity of Novec 7800 to Daphnia magna under semistatic conditions was examined in a limit test according to OECD 202 guidelines. Given a loading rate of 100 mg/L, the geometric mean measured concentration in the test medium was 0.0244 mg/L. No toxicity was observed. As explained in the Analog Reporting Format justifying the readacross, the structural difference between Novec 7700 and Novec 7800 is unlikely to lead to a difference in short-term toxicity to aquatic invertebrates.
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