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Diss Factsheets
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EC number: 203-467-0 | CAS number: 107-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Toxicity Data: List VI 23: 95 - 107
- Reference Type:
- secondary source
- Title:
- HSDB
- Year:
- 2 003
- Bibliographic source:
- http://www.safe.nite.go.jp/english/ghs/11-mhlw-0074e.html
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloroacetonitrile
- EC Number:
- 203-467-0
- EC Name:
- Chloroacetonitrile
- Cas Number:
- 107-14-2
- Molecular formula:
- C2H2ClN
- IUPAC Name:
- 2-chloroacetonitrile
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Normal albino rabbit eyes are selected on the basis of absence of grossly visible staining by a 5-percent aqueous solution of fluorescein sodium, flushed with distilled water 20 seconds after application. (described in Carpenter and Smyth, CHEMICAL BURNS OF THE RABBIT CORNEA, 1946)
Test system
- Controls:
- not specified
- Amount / concentration applied:
- various volumes and concentrations
- Duration of treatment / exposure:
- 18-24 h (described in Carpenter and Smyth, CHEMICAL BURNS OF THE RABBIT CORNEA, 1946)
- Details on study design:
- 0.005 ml. of the undiluted material is applied to the center of the cornea while the lids are retracted. About one minute later, the lids are released. Eighteen to 24 hours later, the eye is examined in strong diffuse daylight, then stained with fluorescein, and the injury scored. Guided by the result and the table of injury grades, additional applications are made until the chemical can be assigned to one of the grades we recognize. The system depends partly on volume and partly on concentration. The combination is necessary to separate the damage produced by chemicals of obviously diverse abilities to injure that cannot be distinguished on the basis of the reaction to 0.005 ml. undiluted. If large volumes are applied, the lids are held closed for one minute before the animal is released. (described in Carpenter and Smyth, CHEMICAL BURNS OF THE RABBIT CORNEA, 1946)
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Remarks:
- Grade 5 indicates a so-called severe burn from 0.005 ml
- Irritant / corrosive response data:
- The degree of injury observed 24 hours after application to rabbits was rated as 5 (the most severe injuries are rated 10) on a scale of 1 to 10 (HSDB (2003)), but it was classified in Category 2 without sub-categorization due to unknown details on a recovery period and so on.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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