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Diss Factsheets
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EC number: 219-440-1 | CAS number: 2437-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Irrittating to skin (GHS Cat.2)
Non-irritating to eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a GLP compliant OECD TG 404 study, Dodecanenitrile was applied semi-occlusively for 4 hours to the shaved skin of three New Zealand White Rabbits. Well-defined up to moderate to severe erythema and slight edema were observed in all three animals. All signs of irritation were fully reversible between day 7 and day 14 post application. Average scores for erythema were 3.0, 3.0 and 2.67 (for 24h, 48h and 72h) in all animals. Scores for oedema were 4.0, 1.7 and 1.7 for the same time points. Based on these study results, the test material Dodecannitrile is considered to be irritating to skin. (GHS Cat.2).
Dodecanenitrile was evaluated for eye irritation in New-Zealand rabbits according to OECD 405 and EU 84/449/EEC B.5 guidelines. 0.1 mL of undiluted test material was instilled in one eye of each animal. The eyes were flushed after 24 hours. Results: No irritation was observed.
Effects on skin irritation/corrosion: irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Available information indicates that alkylnitriles are irritating to the skin, but not irritating to the eyes.
Dermal irritation:
An adequate guideline study with Dodecanenitrile has shown the substance to be irritating to skin.
A similar study performed with Tallownitrile resulted to similar results showing that alsoTallownitrile is considered to be irritating to skin. (GHS Cat.2)
Other available dermal irritation studies other alkylnitriles also indicated dermal irritation but the actual scoring in those studies was not sufficient to reach a Cat.2 classification.
In view of the collective data on dermal irritation on the various alkylnitriles, the weight of evidence indicates that it is considered prudent to classify the alkylnitriles collectively as irritating to skin.
Eye irritation:
Although irritating to the skin, none of the in vivo eye irritation studies performed on the various alkyl nitriles, including Dodecanenitrile, indicated a concern for eye irritation.
Respiratory irritation:
There is no information on possible respiratory irritation. Based on the available information on skin and eye irritation, alkylnitriles are not expected to pose a great concern in this respect. Moreover, based on the very low vapour pressure and water solubility, respiratory irritation is not likely to occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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