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Diss Factsheets
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EC number: 293-165-5 | CAS number: 91052-08-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Sep - 18 Sep 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted in 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- adopted in 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Umwelt, Raumordnung und Landwirtschaft des Landes Nordrhein-Westfalen, Düsseldorf, Germany
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar (Hsd/Win:WU/SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen, Germany
- Weight at study initiation: 261 - 278 g (males), 202 - 220 g (females)
- Housing: individually housed in Makrolon type III cages on soft wood bedding
- Diet: Ssniff R 10 diet in pellet form (laboratory standard rat diet, Ssniff Spezialfutter GmbH, Soest, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 x 50 mm on the dorsolumbar region
- % coverage: 10%
- Type of wrap if used: the treated skin was covered with gauze which was held in place with a semiocclusive dressing encircled firmly around the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treated area of skin was cleaned with corn oil and absorbent paper.
- Time after start of exposure: 24 h
PREPARATION OF DOSING SOLUTION
- Preparation: the powdery substance was suspended in corn oil.
- Amount(s) applied (volume or weight with unit): 5 cm³/kg bw
- Concentration: 40 g/100 cm³ - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: rats were checked at least twice daily for mortality. Animals were observed for clinical signs 30 min after dosing and at hourly intervals on Day 0, thereafter daily.
- Frequency of weighing: on Days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: local dermal irritations were recorded daily.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- No clinical signs of toxicity were observed up to the end of the 14-day observation period.
- Body weight:
- The male rats achieved satisfactory body weight gains throughout the study.
Four female rats showed minimal body weight gain after the first week. One female showed little body weight loss after the first week. At the end of the study, minimal body weight gain was recorded in two female animals and one animal showed no body weight gain. Two female rats achieved satisfactory body weight gains throughout the study. Variation of body weight in this age / body weight range is a physiological finding and not substance-related (see Table 1). - Gross pathology:
- The macroscopical examination on Day 14 revealed no abnormalities.
- Other findings:
- After removal of the dressings 24 h post-application until the end of the study, no skin irritations were noticed.
Any other information on results incl. tables
Table 1. Body weight.
Animal No. |
Body weight on Day (g) |
Body weight gain (g) |
|||||
0 |
7 |
14 |
Week 1 |
% body weight gain |
Week 2 |
% body weight gain |
|
Males |
|
|
|
|
|
|
|
1 |
278 |
296 |
305 |
18 |
6.5 |
9 |
3.0 |
2 |
261 |
278 |
305 |
17 |
6.5 |
27 |
9.7 |
3 |
260 |
278 |
306 |
18 |
6.9 |
28 |
10.1 |
4 |
272 |
298 |
321 |
26 |
9.6 |
23 |
7.7 |
5 |
269 |
294 |
313 |
25 |
9.3 |
19 |
6.5 |
Females |
|
|
|
|
|
|
|
1 |
202 |
209 |
209 |
7 |
3.5 |
0 |
0.0 |
2 |
212 |
213 |
217 |
1 |
0.5 |
4 |
1.9 |
3 |
220 |
213 |
223 |
-7 |
-3.2 |
10 |
4.7 |
4 |
220 |
234 |
250 |
14 |
6.4 |
16 |
6.8 |
5 |
208 |
210 |
215 |
2 |
1.0 |
5 |
2.4 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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