Registration Dossier
Registration Dossier
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EC number: 226-942-4 | CAS number: 5570-77-4
Endpoint summary
Administrative data
Description of key information
Hydrolysis
Hydrolysis of 4-chloro-1-methylpiperidine (CAS no. 5570 -77 -4) is predicted using OECD QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. The estimated half-life of 4-chloro-1-methylpiperidine was estimated to be 92.6 days, indicating that it is not hydrolysable.
Additional information
Hydrolysis
The predicted data for the target substance 4-chloro-1-methylpiperidine and the available data for its structurally similar substance were reviewed for hydrolysis endpoint and are presented as weight of evidence approach as follows:
Hydrolysis of 4-chloro-1-methylpiperidine (CAS no. 5570 -77 -4) is predicted using OECD QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. The estimated half-life of 4-chloro-1-methylpiperidine was estimated to be 9 -2.6 days, indicating that it is not hydrolysable.
As part of a study in which the structurally similar substance 1-ethenylpyrrolidin-2-one (CAS 88 -12 -0) was administered in drinking water, 1-ethenylpyrrolidin-2-one was shown to be stable in drinking water for at least 4 days. Hence it can be considered that the test substance is slowly hydrolysable in water.
Considering above data it can be assumed that the target substance4-chloro-1-methylpiperidineis slowly to negligibly hydrolysable and stable in water.
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