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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11th Aug - 24th Sept 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
UUID SNIF-8b8f06c9-7922-3b8b-b8e1-3f3df2201b93
Author XML Transformation V4.0 Plug-In
Date 2010-08-30 20:14:06 BST
Remarks Successfully migrated to IUCLID 5.5 format.
updated to IUCLID 6
Qualifier:
according to guideline
Guideline:
other: Method C7, Directive 92/69/EEC The figures cited for 25°C were extrapolated from the measurements at higher temperatures
GLP compliance:
yes
Specific details on test material used for the study:
Identity of test material same as for substance defined in section 1
Radiolabelling:
yes
Transformation products:
not measured
Key result
pH:
4
Temp.:
61.2 °C
DT50:
3.3 h
Key result
pH:
4
Temp.:
50.1 °C
DT50:
12.9 h
Key result
pH:
4
Temp.:
40 °C
DT50:
48 h
Key result
pH:
4
Temp.:
25 °C
DT50:
ca. 850 h
Key result
pH:
7
Temp.:
70.2
DT50:
4.7 h
Key result
pH:
7
Temp.:
60.3 °C
DT50:
14.7 h
Key result
pH:
7
Temp.:
50.1 °C
DT50:
70.3 h
Key result
pH:
7
Temp.:
25 °C
DT50:
ca. 7 900 h
Key result
pH:
9
Temp.:
70.1 °C
DT50:
2.7 h
Key result
pH:
9
Temp.:
60.3 °C
DT50:
13.7 h
Conclusions:
The abiotic degradation (hydrolysis) of BMS 233110-01 was investigated at temperatures between 40ºC and 70ºC at pH values of 4, 7 and 9. Hydrolysis was observed at each pH, the rate constants and half-lives were evaluated for each test condition, and data derived for the predicted hydrolysis rates at 20ºC. The rate of reaction was highest at pH 4 and lowest at pH 9.

Description of key information

The abiotic degradation (hydrolysis) of BMS 233110-01 was investigated  at temperatures between 40ºC and 70ºC at pH values of 4, 7 and 9. Hydrolysis  was observed  at each pH, the rate constants and half-lives were evaluated for each test condition, and data derived for the predicted hydrolysis rates at 20ºC. The rate of reaction was highest at pH 4 and lowest at pH 9.

Key value for chemical safety assessment

Half-life for hydrolysis:
7 900 h
at the temperature of:
25 °C

Additional information