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EC number: 228-544-6 | CAS number: 6291-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reveiwed journal.
- Qualifier:
- according to guideline
- Guideline:
- ISO 10253 (Water quality - Marine Algal Growth Inhibition Test with Skeletonema costatum and Phaeodactylum tricornutum)
- Version / remarks:
- No data available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Short term toxicity study of N-Methyl-1,3-propanediamine on the growth of marine algae Skeletonema costatum for 72 hrs.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: (3-aminopropyl)(methyl)amine
- Molecular formula: C4H12N2
- Molecular weight: 88.1528 g/mol
- Smiles notation: N(CCCN)C
- InChl: 1S/C4H12N2/c1-6-4-2-3-5/h6H,2-5H2,1H3
- Substance type: Organic
- Physical state: Liquid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Skeletonema costatum
- Details on test organisms:
- No data available
- Test type:
- static
- Water media type:
- other: Marine water
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- No data available
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- 20 ± 2◦ C
- pH:
- No data available
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Conductivity:
- No data available
- Nominal and measured concentrations:
- 10-10,000 mg/l
- Details on test conditions:
- - No. of organisms per vessel: 3 × 10 3 Cells/ml
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- No. of vessels per vehicle control (replicates): No data available
- Light intensity and quality: All test tubes were incubated with agitation under constant light intensity (60–120 µE/s/m2).
- Test concentrations: 10-10,000 mg/l
- Results used to determine the conditions for the definitive study: Inhibitions of biomass and growth - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 065 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Growth rate and biomass
- Remarks on result:
- other: 95% confidence interval 999-1150 mg/l
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- Growth rate were calculated by linear regression analyses of the logarithmic of algal growth curves for each concentration of chemical and for controls.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the inhibition of growth rate and Area under the growth curves (biomass), the EC50 of chemical 3-Amino-1-methylaminopropane on the Skeletonema costatum was 1065 mg/l.
- Executive summary:
Short term toxicity study of N-Methyl-1,3-propanediamine on the growth of marine algae Skeletonema costatum for 72 hrs. Test was performed by static system. The choice of test concentrations was based on a preliminary test with ten-fold dilutions of the test substance (10–10,000 mg/l), in triplicates.
Based on the inhibition of growth rate and Area under the growth curves (biomass), the EC50 of chemical 3-Amino-1-methylaminopropane on the Skeletonema costatum was 1065 mg/l. With 95% confidence interval (999-1150).
Thus it was concluded that the chemical N-Methyl-1,3-propanediamine was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Reference
In vivo chlorophyll fluorescence was measured daily in a filter fluorometer
Description of key information
Short term toxicity study of N-Methyl-1,3-propanediamine on the growth of marine algae Skeletonema costatum for 72 hrs. Test was performed by static system. The choice of test concentrations was based on a preliminary test with ten-fold dilutions of the test substance (10–10,000 mg/l), in triplicates.
Based on the inhibition of growth rate and Area under the growth curves (biomass), the EC50 of chemical 3-Amino-1-methylaminopropane on the Skeletonema costatum was 1065 mg/l. With 95% confidence interval (999-1150).
Thus it was concluded that the chemical 3-Amino-1-methyl-aminopropane was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 1 065 mg/L
Additional information
Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of (3-aminopropyl)(methyl)amine (6291-84-5) on the growth rate and biomass of algae. The studies are as mentioned below:
In the first key study for the target chemical (3-aminopropyl)(methyl)amine (6291-84-5) International Journal of Greenhouse Gas Control, 2012. Short term toxicity study of N-Methyl-1,3-propanediamine on the growth of marine algae Skeletonema costatum for 72 hrs. Test was performed by static system. The choice of test concentrations was based on a preliminary test with ten-fold dilutions of the test substance (10–10,000 mg/l), in triplicates. Based on the inhibition of growth rate and Area under the growth curves (biomass), the EC50 of chemical 3-Amino-1-methylaminopropane on the Skeletonema costatum was 1065 mg/l. With 95% confidence interval (999-1150). Thus it was concluded that the chemical 3-Amino-1-methyl-aminopropane was nontoxic and can be consider to be not classified as per the CLP classification criteria.
Similarly in the second experimental supporting study for (3-aminopropyl)(methyl)amine, from Energy Procedia 2009, Short term toxicity study of N-Methyl-1,3-propanediamine on the growth of marine algae Skeletonema costatum for 72 hrs. Test was performed by static system. The choice of test concentrations was based on a preliminary test with ten-fold dilutions of the test substance (10–10,000 mg/l), performed in triplicates. Based on the inhibition of growth rate and Area under the growth curves (biomass), the EC50 of chemical 3-Amino-1-methylaminopropane on the Skeletonema costatum was 1500 mg/l. Thus it was concluded that the chemical 3-Amino-1-methyl-aminopropane was nontoxic and can be consider to be not classified as per the CLP classification criteria.
In the third predicted supporting study for the target chemical (3-aminopropyl)(methyl)amine, from EPISUITE, 2017. Based on the prediction done using the EPI Suite ECOSAR version 1.10, the short term toxicity on green algae was predicted for test substance N-Methyl-1,3- propanediamine. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 2129.914 mg/l for green algae for 72 hrs. Based on this value, it can be concluded that the test chemical N-Methyl-1,3-propanediamine can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Thus based on the above data sources for target chemical (3-aminopropyl)(methyl)amine from various experimental studies International Journal of Greenhouse Gas Control, 2012, Energy Procedia 2009, and predicted data, it was summarized that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.
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