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Diss Factsheets
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EC number: 205-471-8 | CAS number: 141-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- According to Regulation (EC) No. 1907/2006, Column 2 of Annex IX, long-term toxicity testing in aquatic invertebrates shall be proposed if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not expected to exhibit toxicity in the aquatic environment. The substance has a very low water solubility (i.e., 0.08994 mg/L) and is considered insoluble in water. Short-term toxicity was not observed in any of the aquatic toxicity tests conducted on an analogue substance through read-across at three trophic levels; in addition, long-term toxicity was not observed in algae. The substance has been determined to be readily biodegradable (i.e., 80% degradation in 28 d and meeting the 10-d window) and is not persistent in the environment; therefore, food chain exposures through secondary poisoning are not expected. Furthermore, studies conducted on analogue substances in higher vertebrates showed that the substance is not expected to exhibit acute oral toxicity, specific target organ toxicity through single or repeated dose oral exposure, genetic toxicity or reproductive toxicity. The substance is a short-chain alkyl ester of a naturally occurring fatty acid (i.e., the methyl ester of 12-hydroxystearic acid), and is expected to undergo catabolism by esterases and lipases in vivo; toxicokinetic studies conducted on analogue substances in mammals demonstrated a pharmacokinetic disposition comparable to that of endogenous triglycerides. Therefore, long-term toxicity testing in aquatic invertebrates is waived.
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
According to Regulation (EC) No. 1907/2006, Column 2 of Annex IX, long-term toxicity testing in aquatic invertebrates shall be proposed if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not expected to exhibit toxicity in the aquatic environment. The substance has a very low water solubility (i.e., 0.08994 mg/L) and is considered insoluble in water. Short-term toxicity was not observed in any of the aquatic toxicity tests conducted on an analogue substance through read-across at three trophic levels; in addition, long-term toxicity was not observed in algae. The substance has been determined to be readily biodegradable (i.e., 80% degradation in 28 d and meeting the 10-d window) and is not persistent in the environment; therefore, food chain exposures through secondary poisoning are not expected. Furthermore, studies conducted on analogue substances in higher vertebrates showed that the substance is not expected to exhibit acute oral toxicity, specific target organ toxicity through single or repeated dose oral exposure, genetic toxicity or reproductive toxicity. The substance is a short-chain alkyl ester of a naturally occurring fatty acid (i.e., the methyl ester of 12-hydroxystearic acid), and is expected to undergo catabolism by esterases and lipases in vivo; toxicokinetic studies conducted on analogue substances in mammals demonstrated a pharmacokinetic disposition comparable to that of endogenous triglycerides. Therefore, long-term toxicity testing in aquatic invertebrates is waived.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.