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Diss Factsheets
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EC number: 212-220-6 | CAS number: 770-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 1996-02-22
Test material
- Reference substance name:
- Phenyl phosphorodichloridate
- EC Number:
- 212-220-6
- EC Name:
- Phenyl phosphorodichloridate
- Cas Number:
- 770-12-7
- Molecular formula:
- C6H5Cl2O2P
- IUPAC Name:
- phenyl dichlorophosphate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd, Moston, Sand bach, Cheshire, UK
- Age at study initiation: 12 to 16 weeks old
- Weight at study initiation: 2.32 to 2.79 kg
- Housing: individually housed in suspended metal cages
- Diet: free access to STANRAB SQC Rabbit Diet, Special Diets Services Ltd, Witham, Essex, UK)
- Water: free access to water
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17°C to 21°C
- Humidity (%): 46% to 65 %
- Air changes (per hr): 15 changes
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5mL
- Duration of treatment / exposure:
- 3 minutes and 1h
- Observation period:
- 24h, 48, 72h, day 7 and day 14
- Number of animals:
- 3
- Details on study design:
- On the day before the test each rabbit was clipped free of fur from the dorsal flank area using veterinary clippers. Only animals with a healthy intact epidermis by gross observation were selected for the study.
One rabbit was initially treated. Three suitable test sites were selected on the back of the rabbit. At each test site a quantity of 0.5 ml of the test material, was introduced under a 2.5 cm x 2.5 cm cotton gauze patch and placed in position on the shorn skin. Each patch was secured in position with a strip of surgical adhesive tape (BLENDERM: approximate size 2.5 cm x 4.0 cm). To prevent the animal interfering with the patches, the trunk of the rabbit was wrapped in an elasticated corset (TUBIGRIP) and the animal was returned to its cage for the duration of the exposure period.
One patch was removed at each of three time points: 3 minutes and 1 hour after application. Due to adverse reactions the third patch was also removed after one hour. Any residual test material was removed by gentle swabbing with cotton wool soaked in 74% Industrial Methylated Spirits.
After consideration of the skin reactions produced in the first animal, two additional animals were treated with 0.5 ml of test material. One patch was applied to the back of each rabbit, and was allowed to remain in contact with the skin for a period of three minutes.
Approximately one hour following the removal of the patches, and 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation and scored according to the following scale from Draize J H, (1977) "Dermal and Eye Toxicity Tests" In: Principles and Procedures for Evaluating the Toxicity of Household Substances, National Academy of Sciences, Washington DC p.31.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive
- Irritation parameter:
- edema score
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive
Any other information on results incl. tables
Individual skin reactions following 1-hour exposure period
Skin reation |
Observation time |
Female N° 69 (2.32 kg) Score /observation |
Erythema / Eschar formation |
1 hour |
4 / green-coloured dermal necrosis covering whole of treatment site |
24 hours |
4 / green-coloured dermal necrosis covering whole of treatment site |
|
48 hours |
4 / green-coloured dermal necrosis covering whole of treatment site. Well-defined erythema surrounding other reaction |
|
72 hours |
4 / green-coloured dermal necrosis covering whole of treatment site. Well-defined erythema surrounding other reaction. Blanching of the skin |
|
7 days |
4 / green-coloured dermal necrosis covering whole of treatment site. Well-defined erythema surrounding other reaction. Blanching of the skin |
|
14 days |
Adverse reactions prevent accurate evaluation of erythema. Ulceration. Animal killed due to ulceration in accordance with company policy |
|
Oedema formation |
1 hour |
4 |
24 hours |
3 |
|
48 hours |
3/ oedema extends ventrally below treatment site |
|
72 hours |
3 |
|
7 days |
3 |
|
14 days |
Adverse reactions prevent accurate evaluation of oedema |
Individual skin reactions following 3-minute exposure period
Skin reation |
Observation time |
Individual scores |
||
Female N° 69 (2.32 kg) |
Female N° 581 (2.79 kg) |
Female N° 160 (2.64 kg) |
||
Erythema / Eschar formation |
1 hour |
2 |
1 |
1 |
24 hours |
2 |
2 |
2 |
|
48 hours |
2 |
2 |
2 |
|
72 hours |
2 |
1 |
2 |
|
7 days |
1 (crust formation) |
0 (slight desquamation) |
1 (crust formation) |
|
14 days |
0 (slight desquamation) |
0 |
0 (moderate desquamation) |
|
Oedema formation |
1 hour |
1 |
1 |
1 |
24 hours |
1 |
1 |
1 |
|
48 hours |
1 |
1 |
1 |
|
72 hours |
1 |
0 |
1 |
|
7 days |
1 |
0 |
0 |
|
14 days |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The phenyl dichlorophosphine is classified as corrosive to rabbit skin.
- Executive summary:
Dermal toxicity of Phenyldichlorophosphate has been determined according to EU B.4 method and OECD test guideline 404 in compliance with GLP. Phenyldichlorophosphate was determined to be corrosive category 1B to the skin.
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