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EC number: 238-947-9 | CAS number: 14874-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not follow modern guideline, but data are reasonaly well documented and scientifically acceptable. Limited reporting of test material (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- A range finding study using groups of two rats (one male, one female) at five dose levels was conducted to identify the highest dose at which no deaths occurred. In the main study, a further group of 10 rats (5 male, 5 female) was treated at this dose.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- EC Number:
- 238-947-9
- EC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Cas Number:
- 14874-82-9
- Molecular formula:
- C7H7O4Rh
- IUPAC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Details on test material:
- - Name of test material (as cited in study report): CB.23 – Rhodium Dicarbonyl Acetylacetonate
- Substance type: Green metallic powder
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Lot/batch No.: no data
- Other: Supplied in a screw topped glass jar.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Olac, Shaws Farm, Blackthorn, Bicester, Oxon
- Age at study initiation: “young adult”
- Weight at study initiation: 170-235 g
- Fasting period before study: overnight
- Housing: 5 rats (of one sex) in polypropylene cages
- Diet (e.g. ad libitum):ad libitum oxoid maintenance diet supplied by Herbert C. Styles (Bewdley) Ltd
- Water (e.g. ad libitum): ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): “thermostatically controlled room”
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): “controlled lighting conditions”
IN-LIFE DATES: From: To: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- A single dose was administed orally by stomach tube using a rubber catheter. Test material was delivered in a total volume of 10 ml vegetable oil.
- Doses:
- Range finding study: 25, 50, 200, 500 and 2000 mg/kg bw.
Main study: 50 mg/kg bw. - No. of animals per sex per dose:
- Range finding study: one rat/sex/dose
Main study: five rats/sex/dose - Control animals:
- no
- Details on study design:
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- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Animals were weighed immediately prior to dosing. The animals were examined immediately after dosing, four-hours after dosing, and then daily for 14 days for signs of toxicity.
- Necropsy of survivors performed: no
- Other examinations performed: none - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 50 - < 500 mg/kg bw
- Mortality:
- In the range-finding study, both the male and the female rats died (24 hrs and 4 days after dosing, respectively) at 2000 mg/kg bw. The females in the 500 and 200 mg/kg bw dose level groups died (at 4 days and 3 days after dosing, respectively). No deaths were seen at the 50 mg/kg bw dose level or below. In the main study, one of the group of five females died at the selected treatment level of 50 mg/kg bw. The remaining females and all five treated males survived the 14 day observation period.
- Clinical signs:
- other: Not reported.]
- Gross pathology:
- Not reported.]
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 value of rhodium dicarbonyl acetylacetonate in rats was established to be within the range of 50-500 mg/kg bw.
- Executive summary:
The acute oral toxicity of rhodium dicarbonyl acetylacetonate was assessed in rats, using a method equivalent to OECD Test Guideline 401. In a range finding study, groups of Sprague-Dawley rats (1/sex/group) were administered the test item at doses of 25, 50, 200, 500 or 2000 mg/kg bw by stomach tube. Both rats died in the 500 and 2000 mg/kg bw dose groups, within four days of treatment. The female rat treated at 200 mg/kg bw died three days post-treatment. Therefore, in the main study, groups of five rats/sex were administered a dose of 50 mg/kg bw. One female rat died three days after treatment. The remaining animals survived the 14 day observation period and were reported to show “no overt signs of toxicity”.
The acute oral median lethal dose (LD50) of rhodium dicarbonyl acetylacetonate was determined to be between 50 and 500 mg/kg bw. Based on the results of this study, rhodium dicarbonyl acetylacetonate should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
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