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EC number: 244-776-0 | CAS number: 22094-93-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EN 15051-2 (Workplace exposure. Measurement of the dustiness of bulk materials - Rotating drum method)
- GLP compliance:
- not specified
- Type of method:
- rotating cylinder
- Details on methods and data evaluation:
- The sample has been divided in eight equal lots of about 35 ml using a rotary riffler, this rotary riffler is especially designed to minimize the loss of any fine dust. One of these divided lots has been used for determining the bulk density and the moisture content as well. The bulk density of the sample has been determined by accurately weighing a volume of 100 cm3 after gentle tapping at the side. This bulk density is used to convert the sample mass to the required volume of approx. 35 cm3 and the sample is further divided to the required 35 cm3. A few grams of each sample have been placed in the moisture analyser and have been heated to 105°C until a stable mass has been reached. The relative mass loss so-obtained has been quantified as moisture content as an independent triplicate.
One of the divided sub lots of about 35 cm3 is accurately weighed and placed in the rotating drum and the airborne dust particles are transferred by an air flow rate of 38 l min-1 to the filter assembly during 1 minute. The airborne dust released is drawn from the dust generation section, through the dust transfer section, into the special designed foam/filter assembly with successively 20 pores per inch foam, 80 pores per inch foam and a glass fibre backing filter. The complete procedure is repeated several times with fresh sample material and clean filters, each dustiness measurement is preceded by a blank run. Dustiness is a relative term and the result obtained will depend on the used test apparatus, the properties of the material and various environmental variables. - Sampling:
- The dust sampling system of the EN 15051-2 Rotating Drum method is constructed in such a way that the largest airborne particles are collected on a foam filter with 20 pores per inch foam. Smaller airborne particles pass through this filter and are collected on a second foam filter with 80 pores per inch foam. Only the smallest airborne particles pass through both foam filters and are collected on a glass fibre backing filter. The dust collected on the glass fibre backing filter is presented as the respirable fraction.
In accordance with the respirable convention described in ISO 7708 the adult respirable fraction shown in Figure 1 is given by a cumulative log-normal distribution with a median diameter of 4.25 μm and a geometric standard deviation of 1.5.2 This results that 100% of the particles with an aerodynamic diameter < 16 μm are classified as respirable and it is assumed that these particles are all collected on the glass fibre backing filter.
According to the respirable convention, 98.7% of the particles collected by the EN 15051 methodology on this glass fibre backing filter then have an aerodynamic particle diameter ≤ 10 μm.
Test material
- Reference substance name:
- 2,2'-[(2,2',5,5'-tetrachloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
- EC Number:
- 244-776-0
- EC Name:
- 2,2'-[(2,2',5,5'-tetrachloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide]
- Cas Number:
- 22094-93-5
- Molecular formula:
- C36H32Cl4N6O4
- IUPAC Name:
- 2,2'-[(2,2',5,5'-tetrachlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]
- Test material form:
- solid: nanoform, no surface treatment
Constituent 1
Data gathering
- Instruments:
- 15051 rotating drum dustiness tester
- Reproducibility:
- The average relative standard deviation (RSD) of the intra RSD is typically below 17%. The relative standard deviations obtained for the independent measurements are all below 8 % and are thus well within the range of RSD values typically found for this methodology, confirming adequate sampling.
Results and discussion
Dustiness indexopen allclose all
- Mean:
- ca. 7 676 mg/kg
- St. dev.:
- 4.8 other: %
- Remarks on result:
- other: inhalable fraction
- Mean:
- ca. 944 mg/kg
- St. dev.:
- 4.2 other: %
- Remarks on result:
- other: thoracic fraction
- Mean:
- ca. 88 mg/kg
- St. dev.:
- 3.9 other: %
- Remarks on result:
- other: respirable fraction
Any other information on results incl. tables
Category of dustiness | Inhalable dustiness mass fraction, mg kg-1 | Thoracic dustiness mass fraction, mg kg-1 | Respirable dustiness mass fraction, mg kg-1 |
very low | <300 | <80 | <10 |
Low | 300-650 | 80-300 | 10-60 |
Moderate | 650-3000 | 300-1000 | 60-210 |
High | >3000 | >1000 | >210 |
Inhalable fraction: high classification
thoracic fraction: moderate classification
respirable fraction: moderate classification
Applicant's summary and conclusion
- Conclusions:
- The substance was tested for dustiness for nanomaterials, following EN15051-2 rotating drum equipment. Under the experimental conditions the test item has the following results, ca. 7676 mg kg-1 for the inhalable fraction (high classification), 944 mg kg-1 for the thoracic fraction (moderate classification) and 88 mg kg-1 for the respirable fraction (moderate classification)
- Executive summary:
The substance was tested for dustiness for nanomaterials, following EN15051-2 rotating drum equipment. Under the experimental conditions the test item has the following results, ca. 7676 mg kg-1 for the inhalable fraction (high classification), 944 mg kg-1 for the thoracic fraction (moderate classification) and 88 mg kg-1 for the respirable fraction (moderate classification)
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