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Diss Factsheets
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EC number: 264-780-6 | CAS number: 64338-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19. March - 2. May 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only females tested
- GLP compliance:
- no
- Remarks:
- performed before GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hostavin N 20
- IUPAC Name:
- Hostavin N 20
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Females (if applicable) nulliparous and non-pregnant: yes
- Weight at study initiation: 160-184 g
- Fasting period before study: yes, 16 h
- Housing: in groups in plastic cages, softwood pellets
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
IN-LIFE DATES: From: 19.3. To: 2.5.1979
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 25% test substance in 2% starch suspension
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
- Amount of vehicle (if gavage): 0.6 - 3.6 mL per animal
- Doses:
- 1000, 3000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 females/group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observation for mortality/clinical signs, weekly weighing
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculation by Probitanalysis according to Linder and Weber
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 1 520 - 3 670
- Mortality:
- 1000 mg/kg bw: 0/10
3000 mg/kg bw: 6/10
5000 mg/kg bw: 9/10 - Clinical signs:
- other: hunchd posture, increased breathing rate, tremor; all symptoms were reversible within 24 h
- Gross pathology:
- Survivors: no changes
Descedents: darkly reddened/spotted lungs and liver
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The median lethal dose of the testsubstance was 2800 mg per kg body weight. Based on the result of this study the test substance is acutely oral toxic, Cat 5.
- Executive summary:
The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1000, 3000, or 5000 mg/kg bw and observed for 14 days. The median lethal dose was 2800 mg per kg body weight. Based on the result of this study the test substance is acutely oral toxic, Cat 5 according to GHS criteria.
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