Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Valid monitored GLP study, followed international guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
Version / remarks:
84/449/449
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
4-chloro-2,5-dimethoxyanilin
IUPAC Name:
4-chloro-2,5-dimethoxyanilin
Constituent 2
Chemical structure
Reference substance name:
4-chloro-2,5-dimethoxyaniline
EC Number:
228-782-0
EC Name:
4-chloro-2,5-dimethoxyaniline
Cas Number:
6358-64-1
Molecular formula:
C8H10ClNO2
IUPAC Name:
4-chloro-2,5-dimethoxyaniline
Details on test material:
:
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
- Name of test material (as cited in study report): Aminochlorhydrochinindimethylether
- Substance type: organic intermediate for pigments
- Physical state: solid
- Analytical purity: > 99.0 %
- Impurities (identity and concentrations): < 0,1 %
- Certificate of analysis: Nr. 3/88 from 1988-01-08
- Product No.: GUDC 105
- Lot/batch:25. Kampagne vom Dezember 1987
- Stability under test conditions: stable up to 210 ° C
- Storage condition of test material: in the dark, under exhaustion
- pH in water: 7-8

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 d

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
35 mg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LOEC
Effect conc.:
50 mg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
111 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality (fish)
Remarks on result:
other: CI: 93,6 - 134
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
180 mg/L
Nominal / measured:
nominal
Conc. based on:
dissolved
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The substance CMEB is valid tested in a GLP m onitored study according to method EC C.2 and OECD 209. The determined tes LC50 is 111 mg/L within a confidence intervall of 93.6 - 134 mg/L.
Executive summary:

The substance CMEB is valid tested in a GLP monitored study according to method EC C.1 and OECD 203.

The determined LC50 is 111 mg/L within a confidence intervall of 93.6 - 134 mg/L.

The NOEC in the current study was determined to be 35 mg/L based on mortality, but symptoms are reported at this concentration.