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EC number: 203-918-1 | CAS number: 111-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No additional data is considered necessary.
Additional information
One key guideline study was identified to evaluate the reproductive toxicity potential of octane-1-thiol.
In a key guideline (OECD 422) reproduction/developmental toxicity screening study (MHLW, 2004; Klimisch score = 1), groups of male and female Sprague-Dawley rats (Crj: CD(SD) IGS, SPF; 12/sex/dose) were administered 0, 10, 50 or 250 mg/kg bw/day of octane-1-thiol (CAS Number 111-88-6) by gavage in olive oil daily for 35 days in males and from 14 days before mating to day 4 of lactation for females. The animals were sacrificed on the 36thday for the males and on the 5thday post-partum/after birth for the females and pups respectively.
No treatment-related mortality occurred during the study. There were no treatment-related effects at any dose on reproductive parameters for males. For females, there was an extension of the mean estrous cycle and gestation length as well as a low delivery index at 250 mg/kg bw/day. Necropsy revealed significant maternal toxicity effects to the stomach, spleen, and thymus in females at 50 and 250 mg/kg bw/day. Females also showed an absolute and relative increase in weight of the spleen, liver, adrenal, a relative weight increase in the kidney, and a decrease in absolute and relative weight in the thymus in 250 mg/kg bw. There were no treatment-related effects at any dose on offspring.
The NOAEL for reproductive toxicity was 250 and 50 mg/kg bw/day for males and females respectively. The NOAEL for maternal toxicity was 10 mg/kg bw/day. The NOAEL for the offspring was 250 mg/kg bw/day.
Short description of key information:
One key guideline study was identified to evaluate the reproductive toxicity potential of octane-1-thiol. No treatment-related effects on reproductiveparameters were observed in male rats. An extension of the mean estrous cycle and gestation length, as well as a low delivery index was observed in female rats dosed at 250 mg/kg bw/day. There was also significant maternal toxicity effects in the stomach, spleen, and thymus of female rats dosed at 50 and 250 mg/kg bw/day. The NOAEL for reproductive toxicity was 250 and 50 mg/kg bw/day for males and females respectively. The NOAEL for maternal toxicity is 10 mg/kg bw/day. The NOAEL for the offspring was determined to be 250 mg/kg bw/day.
Effects on developmental toxicity
Description of key information
No treatment-related developmental effects were seen with octane-1-thiol in a rat reproductive/developmental toxicity screening study. Furthermore, no developmental effects were seen in a pre-natal developmental toxicity study conducted on dodecane-1-thiol, a structural analogue of octane-1-thiol. The NOAEL for developmental toxicity was 250 mg/kg/day for octane-1-thiol and 7.4 ppm (61 mg/m3) for dodecane-1-thiol.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 61 mg/m³
Additional information
In a key guideline (OECD 422) reproduction/developmental toxicity screening study (MHLW, 2004; Klimisch score = 1), groups of male and female Sprague-Dawley rats (Crj: CD(SD) IGS, SPF; 12/sex/dose) were administered 0, 10, 50 or 250 mg/kg bw/day of octane-1-thiol (CAS Number 111-88-6) by gavage in olive oil daily for 35 days in males and from 14 days before mating to day 4 of lactation for females. The animals were sacrificed on the 36thday for the males and on the 5thday post-partum/after birth for the females and pups respectively. There were significant maternal toxicity effects to the stomach, spleen, and thymus in females at 50 and 250 mg/kg bw/day. Females also showed an absolute and relative increase in weight of the spleen, liver, adrenal, a relative weight increase in the kidney, and a decrease in absolute and relative weight in the thymus in 250 mg/kg bw. There were no treatment-related effects at any dose on the offspring. The NOAELs for maternal and developmental toxicity for this study are 10 and 250 mg/kg/day.
A pre-natal rat developmental toxicity study (TG 414) has been conducted on dodecane-1-thiol (Schardein, 1983), a structural analogue of octane-1-thiol. In the range-finding study (Schardein, 1983), pregnant Sprague-Dawley rats (5/dose) were exposed by inhalation to 0, 10-12 ppm (0.083-0.099 mg/L , 0.83, and 4.1 mg/L for 6 hours/day during GD 6-19. Due to early signs of toxicity, the 2 highest dose levels were reduced to 0.30 and 2.0 mg/L. All 5 females exposed to 2.0 mg/L died on GD 9 or 10, and all 5 females exposed to 0.30 mg/L were sacrificed in extremis on GD 12 or 13. All animals in the control group and those exposed to 10-12 ppm survived to scheduled termination. Clinical observations included ocular irritation and nasal discharge at 10-12 ppm (0.083-0.099 mg/L). Females at 10-12 ppm (0.083-0.099 mg/L), showed a slight increase in implantation loss as compared to the controls; however, the values were within the range of the historical control data and not considered biologically significant. The NOAEC for maternal and developmental toxicity was 10-12 ppm (0.083-0.099 mg/L) based on maternal mortality at higher doses.
In the definitive prenatal developmental toxicity study (Schardein, 1983), pregnant Charles River COBS CD rats (25/dose) were exposed via the inhalation route (whole body) to dodecane-1-thiol (CAS number 112-55-0) at concentrations of 0, or 0. 061 mg/L (7.4 ppm) for 6 hrs/day from days 6 through 19 of gestation. Animals were sacrificed on day 19 of gestation and organs such as ovaries and uterine content were examined in addition to the foetuses. Survival was unaffected by exposure. Signs of maternal toxicity included unkept coat, matter in the vagina, ptosis of the eyelids, thinness, body weight decrease and a moribund appearance. The majority of animals also showed hair loss, reddened conjunctiva, dry matter around the nose, and dry peeling skin around the ears. There were no biologically meaningful or statistically significant differences in the total incidence of malformation in foetuses. The developmental NOAEC was therefore determined to be >7.4 ppm (61 mg/m3 or 0.061mg/L).
Based on the data available, octane-1-thiol is not a developmental toxicant.
Read across justification
The use of the read across approach was used to fill the data gaps for octane-1-thiol using dodecane-1-thiol as an analog. Dodecane-1-thiol has similar physiochemical properties to octane-1-thiol and thus the toxicological properties of both substances are expected to be similar.
Justification for classification or non-classification
According to the available data and the criteria for classification of REGULATION (EC) No 1272/2008 and the EU DSD Directive Dir 67/548/EEC, no classification is warranted for reproductive and developmental toxicity.
Additional information
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