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EC number: 239-590-1 | CAS number: 15541-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 November 2010 to 24 November 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in accordance with an internationally recognised method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge was obtained from the aeration tank of municipal sewage treatment works, which treats predominantly domestic waste.
- Laboratory culture: on the day of collection, the sample was passed through a sieve with a mesh of 1 mm2. A sub-sample (ca. 0.25 L) was removed and centrifuged at ca. 3000 rpm for ca. 1 minute and the supernatant removed. The sample was then made up to volume with mineral salts medium (MSM) and centrifuged. This procedure was repeated twice and the sample was aerated until required. Aliquots (10 mL) of a homogenised sample of the washed activated sludge were filtered through dried (approximately 105°C) and pre-weighed Whatman GF/C filter papers. The filters were dried for at least one hour, allowed to cool and then re-weighed. The solids level in the sludge was then calculated and an appropriate volume used to inoculate the MSM to give a final suspended solids concentration of 4 mg/L.
- Method of cultivation: air-saturated ultrapure water was added to each of three, five-litre clear glass vessels followed by the volumes of each MSM stock solution required to prepare five litres of MSM. Each culture bottle was then inoculated and a magnetic stirring bar was added. The vessels were stoppered and each was placed on an electrically-operated magnetic stirrer.
- Storage conditions: the vessels were aerated, for five days, until the day of test initiation (Day 0) with a supply of air that had been treated to remove carbon dioxide by passing it through cylinders containing fused calcium chloride and Carbosorb AS.
- Storage length: 5 days
- Preparation of inoculum for exposure:
- Pretreatment: on Day 0 of the test, the pH of the 5-day old inoculated MSM was determined and adjusted with 5M HCl to 7.4 ± 0.2 as required.
- Concentration of sludge:
- Initial cell/biomass concentration:
- Water filtered: yes
- Type and size of filter used: - Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: standard mineral salts medium
- Additional substrate: none
- Solubilising agent: none used
- Test temperature: 22 ± 2°C
- pH: 7.4 ± 0.2
- pH adjusted: yes
- Aeration of dilution water: yes
- Suspended solids concentration: 4 mg/L
TEST SYSTEM
- Culturing apparatus: Wheaton vials (160 mL capacity) immediately sealed with silicone septa and aluminium crimp seals. The vials were incubated horizontally on an enclosed reciprocating shaker.
- Number of culture flasks/concentration: 5
- Method used to create aerobic conditions: pre-aeration
- Measuring equipment: Carbon Analyser with software and autosampler with septum piercing apparatus.
- Test performed in closed vessels: yes
- Test performed in open system: no
SAMPLING
- Sampling frequency: 0, 7, 14, 21, 28 days.
-Number replicates for analysis: TIC analysis was conducted on three cultures of each group on each sampling occasion except on the
last day of the test, when five cultures were analysed.
- Sampling method: designated cultures were injected with concentrated sodium hydroxide (nominally 7M) and shaken for a further period of approximately one hour. The content of each treated culture was allowed to stand, then carefully transferred from the culture vials to carbon analyser vials and these were then analysed.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Inoculum plus reference substance: yes
- Inoculum plus test substance: yes
- Inoculum plus reference substance plus test substance: yes
STATISTICAL METHODS:
None required. - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- The result of a preliminary solubility trial showed that the test substance was insufficiently soluble in ultrapure (UP) water to prepare a test stock. Therefore, on Day 0 of the test, the test substance (299.5 mg) was weighed into a 50 mL volumetric flask and made up to volume with CO2 free UP water. The contents of the flask were then added to the test vessel. The flask was rinsed with a further three 50 mL volumes of CO2 free water and added to the test
vessel. To ensure similarity in the preparation of all cultures, 200 mL of CO2 free UHP water was added to the control and reference vessels. - Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 7 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 14 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 21 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- The production of CO2 in the control cultures, expressed as a percentage of the nominal organic carbon load of test substance was, at most, 18.8% on Day 21. There was no evidence of CO2 production by mixtures containing MPP above that evolved by the controls during the test.
- Results with reference substance:
- 63.8% degradation in 7 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. As there was no evidence of CO2 production above that of the controls , MPP was considered not to be readily biodegradable under the conditions of this test.
Reference
Percent degradation of reference substance in presence of test substance:
64.9% 7 days
63.2% 14 d
63.6% 21d
61.7% 28 d
Description of key information
MPP is not readily biodegradable in the aquatic environment.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
There was no evidence of CO2 production in test solutions containing MPP above that evolved by the controls during the test.
Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. Therefore, MPP was not considered to be readily biodegradable under the conditions of this test..
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