Registration Dossier
Registration Dossier
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EC number: 280-349-5 | CAS number: 83261-15-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
in vitro
gene mutation in bacteria
In a standardized Ames test comparable to OECD guideline 471, the test substance (purity unknown) was tested for gene mutations in Salmonella typhimurium strains TA100, TA1535, TA98 and TA1537 with or without metabolic activation in doses up to 5000 μg/plate. Two independent standard plate tests were performed. The test substance did not induce any concentration-dependent significant increase in the numbers of revertants in any strain. Weak cytotoxicity was observed in concentrations > 2500 µg/plate only in the treatment without S-9 mix as metabolic activating system. The substance was completely soluble in all tested doses. The numbers of revertant colonies observed on solvent (dimethylsulfoxide) and standard positive control substances were considered to be valid. According to the results of the study, the test substance is thus not mutagenic in the Ames test under the experimental conditions chosen here (BASF 1984).
Short description of key information:
in vitro
Gene mutation in bacteria
Ames test, S. typhimurium TA100, TA1535, TA98 and TA1537 with and without metabolic activation: negative (tested up to 5000 µg/plate, comp. OECD 471; BASF 1984)
Endpoint Conclusion:
Justification for classification or non-classification
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