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EC number: 226-749-5 | CAS number: 5462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Jul 1979 to 26 Jul1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-(p-methoxyphenyl)-2-methylpropionaldehyde
- EC Number:
- 226-749-5
- EC Name:
- 3-(p-methoxyphenyl)-2-methylpropionaldehyde
- Cas Number:
- 5462-06-6
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 3-(4-methoxyphenyl)-2-methylpropanal
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Nicholas Helf
- Age at study initiation: At least 8 weeks
- Weight at study initiation: not specified
- Housing: 2/ cage in suspended wire mesh cages (30"x18"x 18")
- Diet: Fresh purina rabbit chow was freely available
- Water: Fresh water was freely available
- Acclimation period: At least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 21 °C
- Any extraneous material which might produce eye irritation was excluded from the area. The room, exclusively reserved for rabbits on acute tests, was kept clean in accordance with the standards of AAALAC.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
0.1 mL was placed in the conjunctival sac of the eye - Duration of treatment / exposure:
- The test material was placed once in the conjunctival sac of one eye. The lids were held together briefly to insure adequate distribution of the test material.
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 6 animals (5 males, 1 female)
- Details on study design:
- OBSERVATIONS:
The ocular reactions of the cornea, iris and conjunctiva were graded at 1, 2, and 3 days after dosing.
SCORING SYSTEM: Draize scoring system. The scores were interpreted as defined in 16 CFR 1500.42.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3, #4, #5 and #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4, #5 and #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #2, #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #3, #4, #5, #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- other: Not eye irritating
- Remarks:
- in accordance with EU CLP (1272/2008 and its updates)
- Conclusions:
- In an eye irritation study with rabbits, performed similar to OECD 405, no positive corneal , iridal or conjunctival scores were noted at any observation time. Based on the results of this study, the substance is not considered an eye irritant.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 405, was performed to test eye irritation in six New Zealand White rabbits (at least 8 weeks old). 0.1 mL of undiluted test material was placed once in the conjunctival sac of one eye of each of the animals. The untreated eye severed as control. Observations were made after 24, 48 and 72 hours according to the Draize scoring system. No ocular reactions of the cornea and iris were observed. Ocular reactions of the conjunctiva (grade 1) were observed after 24 and 48 hours only, but were not assigned as positive test results. The results show that the substance is not irritating to the eye.
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