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Diss Factsheets
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EC number: 209-141-4 | CAS number: 556-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- reduced post observation time (7 days instead of 14)
- Principles of method if other than guideline:
- In principle, the methods described in the OECD Guideline 401 were used. Several groups of 10 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in suitable vehicle.
- GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methylbut-2-en-1-ol
- EC Number:
- 209-141-4
- EC Name:
- 3-methylbut-2-en-1-ol
- Cas Number:
- 556-82-1
- Molecular formula:
- C5H10O
- IUPAC Name:
- 3-methylbut-2-en-1-ol
- Details on test material:
- Name of test substance: 3-Methylbut-2-en-1-ol (Prenol)
Purity: 95 %
Impurities: no further data on impurities given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Average weight at study initiation: 160-260 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water; emulsion in water containing traganth
- Details on oral exposure:
- - Concentration in vehicle: The doses were administered at concentrations of 2% (0.2 ml/kg bw), 20% (1.6, 2.0 and 2.5 ml/kg bw), and 30% (3.2 and 6.4 ml/kg bw) aqueous emulsions, respectively.
- Doses:
- 172, 1376, 1720, 2150, 2752 and 5504 mg/kg bw;
the original values were reported as 0.2, 1.6, 2.0, 2.5, 3.2 and 6.4 ml/kg bw. The mg/kg bw doses were based on a density of 0.86 g/ml at 20 °C. - No. of animals per sex per dose:
- 10 animals per sex per dose.
- Control animals:
- no
- Details on study design:
- Animals were inspected for signs of pharmacologic or toxicologic effects during a 7 days post observation period.
Body weight was measured before dosing.
At the end of the observation period, survivors were sacrificed and necropsied as were animals that died.
The LD50 value was estimated (calculation method not mentioned in the raw data).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 591 mg/kg bw
- Remarks on result:
- other: LD50 value was reported to be ca. 1.85 ml/kg bw
- Mortality:
- No deaths occurred at the lower doses up to 1.6 ml/kg bw. All animals died at 2.0 ml/kg bw and above.
Time of death and number of deaths at each dose:
- 6.4 ml/kg bw: 10/10 males and 10/10 females died within 24 hrs
- 3.2 ml/kg bw: 10/10 males and 10/10 females died within 24 hrs
- 2.5 ml/kg bw: 9/10 males and 10/10 females died within 24 hrs
- 2.0 ml/kg bw: 7/10 males and 10/10 females died within 24 hrs
- 1.6 ml/kg bw: 0/10 males and 0/10 females died within 7 days
- 0.2 ml/kg bw: 0/10 males and 0/10 females died within 7 days
From these data a LD50 value was estimated to be 1591 mg/kg bw after 7 days. The original LD50 value was reported to be ca. 1.85 ml/kg bw. - Clinical signs:
- other: At 6.4 to 2.0 ml/kg bw: Immediately after application, staggering, abdominal and lateral position, partly dorsal position, apathy, laboured and irregular breathing, secretion out of eyes and mouth, reddened eyes and ears. In the post observation days, ca
- Gross pathology:
- In 2 animals that died after application of 2.5 ml/kg bw, stomach dilated and filled with liquid, all other animals without findings in the inner organs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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