Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-219-2 | CAS number: 12135-22-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not stated in paper, but submitted for publication in 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although the study is not conducted to a modern protocol and is somewhat limited, it is nevertheless fairly well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds
- Author:
- Campbell KI, George EL, Hall LL and Stara JF
- Year:
- 1 975
- Bibliographic source:
- Archives of Environmental Health 30, 168-170
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dermal irritancy asessed using male albino rabbits using procedures and evaluation criteria adopted from those in use by the National Institute for Occupational Safety and Health, ... a modification of the official Food and Drug Administration procedure [1973]"
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- Palladium monoxide
- EC Number:
- 215-218-3
- EC Name:
- Palladium monoxide
- Cas Number:
- 1314-08-5
- Molecular formula:
- OPd
- IUPAC Name:
- palladium monoxide
- Details on test material:
- - Name of test material (as cited in study report): Palladium monoxide
- Other: no further details given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Pairs of test sites, each 2 cm x 2 cm, on the closely clipped dorsolaterals aspects of each animal, one side abraded and the other side intact
- Vehicle:
- water
- Remarks:
- 0.1 ml
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- skin reactions scored immediately on removal of patch and 48 hours later
- Number of animals:
- Total of 6 rabbits, with up to 7 pairs of test sites each, used to test 14 test substances, some substances tested more than once
- Details on study design:
- Pairs of test sites, each 2 cm x 2 cm, on the closely clipped dorsolaterals aspects of each animal, one side abraded and the other side intact; Test substances in solid (powder) state were mixed with water (0.1 g quantity mixed with 0.1 ml deionised water) and spread over each site; after application of test substances [several probably tested simultaneously on each animal], test sites occluded; 24 hours later, coverings removed and test sites gently washed with soap, rinsed and dried; skin reactions scored immediately and 48 hours later; evaluation on a grading scale from 0 to 4 [similar to Draize scale]
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- single test rating or average of two or three
- Time point:
- other: 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Severity rating for both intact and abraded skin sites
- Irritant / corrosive response data:
- Average skin reaction for 24 and 72 hours after the start of treatment calculated for intact and abraded skin [no individual scores or any further information presented in paper]
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Palladium monoxide was not irritant in a limited (pre-GLP) study, involving 24-hr occluded application to the intact and abraded skin of 6 male rabbits.
- Executive summary:
In a pre-GLP study, the dermal irritancy of 14 materials, including palladium monoxide, was assessed in albino rabbits. Test materials, mixed with water, were applied to intact and abraded skin of 6 male albino rabbits as 24-hour occluded patches. Coverings were then removed and sites scored immediately and 48 hours later, using a scale from 0 (non-irritant) to 4 (corrosive).
Palladium monoxide failed to give any indication of irritation (score 0) on both intact and abraded skin (mean of reactions at 24 and 72 hours).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.