3-phenylpropionic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice

Author:

E. W. Schafer, Jr. and W. A. Bowles, Jr.

Year:

1985

Bibliographic source:

Arch. Environ. Contain. Toxicol. 14, 111-129 (1985)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity study of 3-phenylpropanoic acid in mice

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-phenylpropionic acid

EC Number:

207-924-5

EC Name:

3-phenylpropionic acid

Cas Number:

501-52-0

Molecular formula:

C9H10O2

IUPAC Name:

3-phenylpropanoic acid

Details on test material:

SMILES:OC(=O)CCc1ccccc1

Specific details on test material used for the study:

- Name of test material (as cited in study report): 3-Phenylpropionic acid
- Molecular formula (if other than submission substance): C9H10O2
- Molecular weight (if other than submission substance): 150.176 g/mole
- Substance type: Organic

Test animals

Species:

mouse

Strain:

other: Deer

Remarks:

Peromyscus maniculatus

Sex:

not specified

Details on test animals or test system and environmental conditions:

- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: Animlas were individually caged.
- Diet (e.g. ad libitum): An alternate less preferred food (laboratory rodent pellets available ad lib.
- Water (e.g. ad libitum): water was available ad lib.
- Acclimation period: No data available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: water, corn oil, or 1.0% carbopol as carriers

Details on oral exposure:

Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred

Doses:

No data available

No. of animals per sex per dose:

approximately 6 animals

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 3 days
- Other examinations performed: Mortality observed

Statistics:

The statistical method used to estimate the acute oral LDs0 was that of Thompson (1948) and Thompson and Weil (1952).

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 1 600 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No 50 % mortality observed

Mortality:

No 50 % mortality was observed in treated mice at 1600 mg/kg bw

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Approximate LD50 was considered to be > 1600 mg/kg bw when Deer mice were treated with 3-phenylpropanoic acid orally by gavage.

Executive summary:

In a acute oral toxicity study, Deer mice were treated with 3-phenylpropanoic acid in a graduated dosage scale by gavage using water, corn oil, or 1.0% carbopol as carriers and observed for mortality for 3 days. No 50 % mortality was observed in treated mice at 1600 mg/kg bw. Therefore, Approximate LD50 was considered to be > 1600 mg/kg bw when Deer mice were treated with 3-phenylpropanoic acid orally by gavage.