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EC number: 204-249-8 | CAS number: 118-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study to GLP standards with no deviations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hydroxychloroquine
- EC Number:
- 204-249-8
- EC Name:
- Hydroxychloroquine
- Cas Number:
- 118-42-3
- Molecular formula:
- C18H26ClN3O
- IUPAC Name:
- 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol
- Test material form:
- solid
- Remarks:
- white solid powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material:
HYDROXYCHLOROQUINE (CAS N°118-42-3) – Batch 5U054 (Synonym: PLAQUENIL)
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Rouen system treatment plant on March 15th, 2016.
- Method of cultivation: This sludge was pre-conditioned to the experimental conditions, but not pre-adapted to the test substance. The pre-conditioning consisted of aerating activated sludge (in mineral medium) for 7 days at the test temperature. The inoculum was taken from the supernatant of this pre-conditioned activated sludge. - Duration of test (contact time):
- 28 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21°C +/- 1°C
- Continuous darkness: no
SAMPLING
- Sampling frequency: 0.1 days
- Sampling method: The BOD (Biological Oxygen Demand) values were given by OXITOP OC 110 Controller
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2
- Abiotic sterile control: 1
- Toxicity control: 1
- Other: Procedure control: One flask
Reference substanceopen allclose all
- Reference substance:
- other: Nitrite
- Reference substance:
- other: Nitrate
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Preliminary study:
- None
- Test performance:
- Validity criteria were fulfilled.
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 1
- Sampling time:
- 28
- Remarks on result:
- other: Zero degradation recorded
- Details on results:
- Not Readily Biodegradable
BOD5 / COD results
- Results with reference substance:
- 95% biodegradation after 28 days
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The reliable OECD 301F Guideline study on ready biodegradability reported a degradation rate of the test item of 0% after 28 days. Therefore, the test item is considered to be not readily biodegradable.
- Executive summary:
The reliable OECD 301F Guideline study on ready biodegradability reported a degradation rate of hydroxychloroquine of 0% after 28 days. Therefore, hydroxychloroquine is considered to be not readily biodegradable.
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