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EC number: 271-114-8 | CAS number: 68515-88-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from Australian Safety and Compensation Council and US Environmental Protection Agency
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME (NICNAS)
- Author:
- Australian Safety and Compensation Council
- Year:
- 2 006
- Bibliographic source:
- NICNAS, FULL PUBLIC REPORT: STD/1159, 24 April 2006
- Reference Type:
- secondary source
- Title:
- Robust summary alkyl sulfide catetgory CAS # 68515-88-8 health elements: Acute toxicity
- Author:
- US Environmental Protection Agency
- Year:
- 2 000
- Bibliographic source:
- US Environmental Protection Agency, AR201-12549bZ, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSA Regulations 16 CFR 1500.40
- Principles of method if other than guideline:
- Acute dermal toxicity study of Pentene, 2, 4, 4-trimethyl-, sulfurized in rabbits
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- EC Number:
- 271-114-8
- EC Name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- Cas Number:
- 68515-88-8
- Molecular formula:
- C24H50S8
- IUPAC Name:
- 1-(2,4,4-trimethyl-1-{[(2,4,4-trimethylpentan-2-yl)disulfanyl]disulfanyl}pentan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)tetrasulfane
- Details on test material:
- SMILES:CC(C)(C)CC(C)(C)SSSSCC(C)(CC(C)(C)C)SSSSC(C)(C)CC(C)(C)C
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Pentene, 2, 4, 4-trimethyl-, sulfurized
- EC name: Pentene, 2,4,4-trimethyl-, sulfurized
- Molecular formula: C24H50S8
- Molecular weight: 594.141 g/mole (As in Chem exper)
- Substance type: Organic
- Physical state: Liquid
- Purity: 97 %
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- Mineral oil-based material dosed undiluted
- Details on dermal exposure:
- The sample was applied to unabraded shaved skin under impervious occlusion for 24 hours at a limit dose of 2.0 mg/kg At the end of the 24-hour exposure period, the wrapping was removed any unabsorbed test material remaining on the skin was removed by gentle sponging using a paper towel moistened with mineral oil
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequently on the day of treatment. Thereafter, all surviving rabbits were examined for outward signs of toxicity one per day, for the entire 14-day observation period. Individual weights were recorded on the day of dosage, weekly thereafter and prior to sacrifice.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight and gross pathology were examined. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 50 % mortality observed
- Mortality:
- One rabbit died on day 14 of the study.
- Clinical signs:
- other: Bloated appearance and Signs of dehydrationIn was observed in dead male rats.
- Gross pathology:
- No formed fecal material in the intestinal tract were noted for the one mortality and no gross pathological changes were observed in treated female rats.
- Other findings:
- In the male rat, mild skin erythema and mild to moderate edema were observed after unwrapping at 24 hours. Slight to mild skin irritation noted at 7 day was completely resolved by day 14.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 2000 mg/kg for when male and female New Zealand white rabbit were exposed to Pentene, 2, 4, 4-trimethyl-, sulfurized.
- Executive summary:
In acute dermal toxicity study, male and femaleNew Zealand white rabbit wereexposed toPentene, 2, 4, 4-trimethyl-, sulfurized in the concentration of 2000 mg/kg.Results shows that one male rabbit is died and all other survive till the end of study. Bloated appearance and Signs of dehydrationIn was observed in dead male rats. One male and female rat decrease in body weight were observed on day 7. In the male rat, mild skin erythema and mild to moderate edema were observed after unwrapping at 24 hours. Slight to mild skin irritation noted at 7 day was completely resolved by day 14. No formed fecal material in the intestinal tract was noted for the one mortality and no gross pathological changes were observed in treated female rats. Therefore, LD50 was considered to be > 2000 mg/kg when male and female New Zealand white rabbit were exposed to Pentene, 2, 4, 4-trimethyl-, sulfurized for 24 hour dermally.
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