Registration Dossier
Registration Dossier
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EC number: 203-606-5 | CAS number: 108-68-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Of the two studies available, the study on 3,5 xylenol returned an equivocal result. Whilst the author of this study concluded that the test substance, 3,5 xylenol did not exhibit any skin sensitising potential, due to similar skin reactions being elicted by the solvent and the test preparation, the outcome of the study could not be concluded with confidence. The study conducted on 2,4 xyelnol returned a positve result, furthermore, no reactivity with the solvent was observed.
Whilst it could be concluded that the skin sensitisation endpoint would need to be repeated to obtain an unequivocal result, data provided for 2,4 xylenol (a structurally similar analogue) confirms that the 2,4 isomer has clear skin sensitising properties. Therefore the approach here provides evidence that the 3,5 isomer may potenitally have skin sensitising properties, and therefore would negate any further in vivo investigation of this endpoint.
Migrated from Short description of key information:
Guinea pig maximisation study on 3,5 xylenol - Weimann 1999 (supporting study)
Guinea pig maximisation study on 2,4 xylenol - Weimann 1998 (key study)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
N/A
Justification for classification or non-classification
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