Ethyl 4,4,4-trifluoroacetoacetate

Endpoint summary

Additional information

Acute fish toxicity:

The acute toxicity of P5117 to the rainbow trout was assessed under semistatic (24 h renewal) exposure conditions over a period of 96 hours using methods based on OECD No. 203 and EU method C.1. Neither the 96-hour median lethal concentration (LC50) nor the no-observed-effect concentration (NOEC) were identified but both must be >= 100 mg/l (nominal). It was concluded that P5117 was not acutely toxic to rainbow trout under the test conditions, at nominal exposure concentrations up to and including 100 mg/l.

Acute daphnia toxicity:

The acute toxicity of P5117 to daphnia magna was assessed under semistatic (24 h renewal) exposure conditions over a period of 48 hours using methods based on OECD No. 202 and EU method C.2. Because attempts to develop a method of chemical analysis for P5117 were unsuccessful, exposure concentrations were not verified during the test. The 24- and 48-hour median effect concentrations (EC50s) for immobility, based on nominal concentrations of P5117, were 31.6 mg/l and 27.2 mg/l respectively. The no-observed-effect concentration (NOEC) was 10 mg/I. It was concluded that P5117 was harmful to daphnia magna under the test conditions.

Toxicity to activated sludge:

The effect of P5117 on the respiration rate of activated sludge was assessed by the methods detailed in EC Directive 87/302, 'Biodegradation - Activated Sludge Respiration Inhibition test' and OECD Test Guideline 209, 'Activated Sludge, Respiration Inhibition test'. Two tests were conducted: a preliminary screen, at nominal concentrations of 1, 10 and 100 mg/l and a final limit test at 100 mg/l. P5117 had no inhibitory effect on the respiration rate of activated sludge at any of the concentrations employed in the test. The EC20, EC50 and EC80 of the test material could not therefore be calculated but these must be greater than 100 mg/l, the highest tested level.