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EC number: 500-315-8 | CAS number: 127087-87-0 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL report .
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ICI SURFACTANTS (POLYOXYETHYLENE 8 NONYLPHENOL) TOXICOLOGY SUMMARY REPORT, WITH COVER LEITER DATED 4/1/1997 (SANITIZED)
- Author:
- ICI Surfactant
- Year:
- 1 997
- Bibliographic source:
- ICI Surfactant. Toxicology Summery report, OTS0558989, 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To evaluate the skin sensitization potential of Poly(oxy-1,2-ethanediyl), .alpha.-(4-nonylphenyl)-.omega.-hydroxy-, branched in human.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 4-Nonylphenol, branched, ethoxylated
- EC Number:
- 500-315-8
- EC Name:
- 4-Nonylphenol, branched, ethoxylated
- Cas Number:
- 127087-87-0
- Molecular formula:
- C25H44O6
- IUPAC Name:
- 2-{2-[2-(4-nonylphenoxy)ethoxy]ethoxy}ethan-1-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type:Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Nonylphenol, branched, ethoxylated
- Molecular formula : C17H28O2
- Molecular weight : 264.409 g/mol
- Substance type: Organic
- Physical state: Liquid
SMILES:CCCC(C)CC(C)Cc1ccc(OCCOCCOCCOCCOCCO)cc1
In vivo test system
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Remarks:
- Not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- one inch square piece of absorbent cotton twill and allowed to remain on the
skin - Day(s)/duration:
- 72 hours
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- one inch square piece of absorbent cotton twill and allowed to remain on the
skin - Day(s)/duration:
- 72 hour
- No. of animals per dose:
- 50 human volunteers
- Details on study design:
- Details on study design
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Exposure period: 72hr
- Test groups: 50
- Control group: No data available
- Site: one inch square piece of absorbent cotton twill and allowed to remain on the Skin
- Frequency of applications: No data available
- Duration:72hr
- Concentrations: No data available
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge: After 7 days of rest period
- Exposure period:72 hr
- Test groups: 50
- Control group: No data available
- Site: No data available
- Concentrations: No data available
- Evaluation (hr after challenge): after 72 hr - Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- rechallenge
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- one inch square piece of absorbent cotton twill and allowed to remain on the Skin
- No. with + reactions:
- 0
- Total no. in group:
- 50
- Clinical observations:
- No skin sensitization effect was observed.
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- Skin sensitizing study was conducted for 4-Nonylphenol, branched, ethoxylated (127087-87-0)on 50 human volunteers. The test substancewas considered to be not sensitizing in human.
- Executive summary:
Skin sensitizing study was conducted for 4-Nonylphenol, branched, ethoxylated (127087-87-0)on 50 human volunteers. The test substance was applied on skin as one inch square piece of absorbent cotton twill for 72 hours. After 72 hours, itwasremoved and the skinwasscored. Seven days after the induction exposure, the test material was reapplied in the same manner and allowed to remain on the skin for 72 hours. After 72 hours of challenge exposure the patch was removed .The skin was scored for sensitization effect. No skin sensitization was observed in any 50 volunteer. So 4-Nonylphenol, branched, ethoxylated (127087-87-0) was considered to be non-skin sensitizing in human.
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