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EC number: 234-324-0 | CAS number: 11099-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
uehler test was performed to assess the dermal sensitization potential of the test chemical. The study was performed according to OECD 406 Guidelines.
In the test chemical treated animals, very light erythema and edema was observed in 2 of 10 treated animals during Induction Phase I, and in 3 of 10 animals in Induction Phase II; no skin irritation was observed in the control animals. Skin irritation was not observed in the control or test chemical-treated animals in Induction Phase III or at challenge.
Hence, the test chemical was considered to be not sensitizing to skin.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- Buehler test was performed to assess the dermal sensitization potential of the test chemical
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- not specified
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available.
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- iNDUCTION I- undiluted
INDUCTION II- undiluted
INDUCTION III- undiluted - Day(s)/duration:
- No data available
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: MEH 56 corn oil
- Concentration / amount:
- 50% test chemical in MEH 56 corn oil
- Day(s)/duration:
- No data available
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- Total:30
Test group:20
control :10 - Details on study design:
- Details on study design
RANGE FINDING TESTS: Pretests were conducted to determine the dose levels used in induction and challenge.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: No data available
- Test groups:20
- Control group:10
- Site: No data available
- Frequency of applications: No data available
- Duration: No data available
- Concentrations: undiluted
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge: No data available
- Exposure period: No data available
- Test groups:20
- Control group:10
- Site: No data available
- Concentrations: 50% test chemical in MEH 56 corn oil
- Evaluation (hr after challenge): - Challenge controls:
- Yes
- Positive control substance(s):
- not specified
- Key result
- Reading:
- other: Challenge
- Group:
- test chemical
- Dose level:
- 50% test chemical in MEH 56 corn oi
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- Skin irritation was not observed in the control or test chemical-treated animals in Induction Phase III or at challenge.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- In the test chemical treated animals, very light erythema and edema was observed in 2 of 10 treated animals during Induction Phase I, and in 3 of 10 animals in Induction Phase II; no skin irritation was observed in the control animals. Skin irritation was not observed in the control or test chemical-treated animals in Induction Phase III or at challenge.
Hence, the test chemical was considered to be not sensitizing to skin. - Executive summary:
Buehler test was performed to assess the dermal sensitization potential of the test chemical. The study was performed according to OECD 406 Guidelines.Pretests were conducted to determine the dose levels used in induction and challenge. A group of guinea pigs (strain not specified; 10 control animals and 20 treated animals in each study) were induced twice with undiluted occlusive epicutaneous exposures to the test chemical. They were induced for the third time, and challenged, with an occlusive epicutaneous exposure to 50% test chemical in MEH 56 corn oil.
In the test chemical treated animals, very light erythema and edema was observed in 2 of 10 treated animals during Induction Phase I, and in 3 of 10 animals in Induction Phase II; no skin irritation was observed in the control animals. Skin irritation was not observed in the control or test chemical-treated animals in Induction Phase III or at challenge.
Hence, the test chemical was considered to be not sensitizing to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Various studies have been reviewed to determine the skin sensitization potential of the test chemical in living organisms. These include in vivo experimental studies performed on Guinea pigs for the test chemical.
Buehler test was performed to assess the dermal sensitization potential of the test chemical. The study was performed according to OECD 406 Guidelines. Pretests were conducted to determine the dose levels used in induction and challenge. A group of guinea pigs (strain not specified; 10 control animals and 20 treated animals in each study) were induced twice with undiluted occlusive epicutaneous exposures to the test chemical. They were induced for the third time, and challenged, with an occlusive epicutaneous exposure to 50% test chemical in MEH 56 corn oil.
In the test chemical treated animals, very light erythema and edema was observed in 2 of 10 treated animals during Induction Phase I, and in 3 of 10 animals in Induction Phase II; no skin irritation was observed in the control animals. Skin irritation was not observed in the control or test chemical-treated animals in Induction Phase III or at challenge.
Hence, the test chemical was considered to be not sensitizing to skin.
This is supported by the results of another Buehler test performed in guinea pigs to evaluate the sensitization potential of the test chemical. The study was performed according to OECD 406 Guidelines. Pretests were conducted to determine the dose levels used in induction and challenge.
30 guinea pigs were used for the study. 3 induction exposures were carried out as follows-
1stinduction- undiluted occlusive epicutaneous
2nd Induction- undiluted occlusive epicutaneous
3rd Induction- undiluted
After the third induction phase, the test animals were rested for a suitable period, and later subjected to challenge exposure using undiluted test chemical under occlusive conditions.
There were no substance related effects or influence on body weight in either test or control animals. There was no skin irritation observed in either test or control animals in Induction Phase III, I, II or in the Challenge Phase.
Hence, the test chemical was considered to be not sensitizing to skin.
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not sensitizing to skin. Comparing the above annotations with the criteria of CLP Regulations, the test chemical can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not sensitizing to skin. Comparing the above annotations with the criteria of CLP Regulations, the test chemical can be classified under the category “Not Classified”.
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