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Diss Factsheets
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EC number: 205-209-2 | CAS number: 135-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- performed prior to guideline and GLP implementation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: company guideline similar to OECD 401
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- performed prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-hydroxy-3'-nitro-2-naphthanilide
- EC Number:
- 205-209-2
- EC Name:
- 3-hydroxy-3'-nitro-2-naphthanilide
- Cas Number:
- 135-65-9
- Molecular formula:
- C17H12N2O4
- IUPAC Name:
- 3-hydroxy-N-(3-nitrophenyl)-2-naphthamide
- Test material form:
- solid
- Details on test material:
- purity: 99.7%
Product number HKAG 155
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 108 - 136 g, mean: 120 g
- Fasting period before study: 16 h
- Housing: Plastic cage, wood shavings bedding
- Diet (e.g. ad libitum): ALTROMIN 1324, Altromin GmbH in Lage/Lippe, ad libitum
- Water (e.g. ad libitum):tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- no abnormal findings
- Other findings:
- no other findings reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- The test item has not to be classified as acutely toxic by the oral route according to Regulation (EC) No 1272/2008.
- Conclusions:
- LD50: > 5000 mg/kg bw, no other abnormalities observed
Therefore, the test item has not to be classified as acutely toxic by the oral route (including STOT SE) according to Regulation (EC) No 1272/2008. - Executive summary:
The substance was tested for acute oral toxicity according to a company guideline similar to OECD 401. 10 female SPF-Wistar-rats were administered a 25% suspension of the test item in sesame oil by gavage. A single dose of 5000 mg/kg bw was used. The observation time after application was 14 days. No mortality occured and the section of the animals resulted in no significant findings.
The LD50 is determined to be greater than 5000 mg/kg bw
Therefore, the test item has not to be classified as acutely toxic by the oral route (including STOT SE) according to Regulation (EC) No 1272/2008.
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