Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 September 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test was conducted according to the principles of GLP using HPLC method. Shake Flask method in progress.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- other: Solid
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -5.17 - 3.98
- Remarks on result:
- other: No unit
- Details on results:
- The calibration graph and reference standard data used for this determination is displayed in Figure 4.1 (see attached background material) with chromatographic profiles shown in Figure 4.2 (see attached background material). The chromatograms for the test material in Figure 4.2 (see attached background material) show five peaks. The capacity factor, k, for the first peak was negative therefore the log Pow value could not be accurately quantified. A value of log Pow = -5.17 was assumed to allow the calculation of the mean CHARM value for the test material. Calculations were performed on duplicate analytical results obtained for the test material and are given in Table 4.3 (see attached background material).
The mean CHARM weighted average log Pow for the soluble components of VX10104SQ (Lot# NES426-075) was calculated to be 2.1.
The range of log Pow for the five peaks observed was from -5.17 to 3.98.
Applicant's summary and conclusion
- Conclusions:
- The mean CHARM weighted average log Pow for the soluble components of VX10104SQ (Lot# NES426-075) was calculated to be 2.1.
The range of log Pow for the five peaks observed was from -5.17 to 3.98. - Executive summary:
The partition coefficient of the test substance was measured based on OECD guideline 117: "Determination of the n-octano/lwater partition coefficient by HPLC".
The range of log Pow for the five peaks observed was from -5.17 to 3.98.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
