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EC number: 207-321-7 | CAS number: 462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: non-irritant (m); rabbit; according to OECD TG 404; GLP; K1; undiluted 0.5 mL test substance
Eye irritation: serious damage (m); rabbit; no guideline followed; GLP not specified; K2; 0.1 mL test substance as 10, 5, or 1 % solution --> Cat. 1, H318: causes serious eye damage
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- observation period 16 days
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Limited, Wyton, Huntingdon
- Age at study initiation: young adult
- Housing: single housing in aluminium cages with grid floors beneath which were peat moss filled trays
- Diet: Standard Rabbit Diet (Special Diets Services, Witham, Essex) ad libitum
- Water: Tap water ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-20
- Humidity (%): 52 (mean)
- Photoperiod (hrs dark / hrs light): 12 / 12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 16 days; skin reactions were assessed 1 h, 24 h, 48 h, 72 h, 7 d and 16 d after patch removal
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- Type of wrap if used: 2.5 cm x 2.5 cm patch of gauze covered with Micropore tape, and the trunk was loosely bound with Elastoplast Elastic Bandage
REMOVAL OF TEST SUBSTANCE
- Washing: with water dampened tissues
- Time after start of exposure: 4 hours
SCORING SYSTEM: OECD recommended scoring system - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.333
- Max. score:
- 4
- Reversibility:
- fully reversible within: 16 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- other: animals #1 - #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Slight erythema was noted in one rabbit 72 h and 7 days after patch removal. This reaction had fully reversed by 16 days after patch removal. No other reactions were noted.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Fluorobenzene is practically non-irritationg to rabbit skin.
Reference
Skin Reaction Scores:
Rabbit No. |
Erythema |
Edema |
||||||||||
1 h |
24 h |
48 h |
72 h |
7 d |
16 d |
1 h |
24 h |
48 h |
72 h |
7 d |
16 d |
|
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available. Peer-reviewed database.
- Principles of method if other than guideline:
- 0.1 ml TS was instilled into the conjunctival sac of the rabbit eye either neat or as a 10, 5 or 1% solution in sesame oil. The eyes were examined 1, 3, 7, 24, 48 and 72 hours and 6 days after instillation.
- GLP compliance:
- no
- Species:
- rabbit
- Vehicle:
- other: sesame oil
- Amount / concentration applied:
- - Amount applied: 0.1 ml
- Concentration: undiluted, 10, 5 or 1% - Observation period (in vivo):
- 6 days
- Number of animals or in vitro replicates:
- 5
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: not specified
- Score:
- > 0
- Reversibility:
- not specified
- Remarks on result:
- other: after application of 0.1 ml undiluted TS
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: not specified
- Score:
- > 0
- Reversibility:
- not specified
- Remarks on result:
- other: after application of 0.1 ml undiluted TS
- Irritant / corrosive response data:
- The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
Reference
The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008.
Based on the available data that only one of three animals showed a slight and albeit reversible reaction to the test substance a classification for skin irritation / corrosion is not justified under Regulation No. 1272/2008, as amended for the seventeenth time in Regulation (EC) No. 2021/849.
For eye irritation the test substance treatment caused an irritant reaction in the eyes of 4 out of 5 animals and with no data available on reversibility this warrants the classification for serious eye damage Cat. 1 under Regulation (EC) No. 1272/2008, as amended for the seventeenth time in Regulation (EC) No. 2021/849.
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