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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance material monograph for p-cresylacetate
Author:
D. L.J Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issue 3, June 1974, Page 391

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Skin irritation potentials of p-tolyl acetate (CAS No. 140-39-9) were investigated in rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-tolyl acetate
EC Number:
205-413-1
EC Name:
p-tolyl acetate
Cas Number:
140-39-6
Molecular formula:
C9H10O2
IUPAC Name:
4-methylphenyl acetate
Test material form:
liquid
Specific details on test material used for the study:
Name of test material (as cited in study report): p-cresyl acetate
Molecular formula: C9H10O2
Molecular weight: 150.176 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
full strength
Duration of treatment / exposure:
no data available
Observation period:
no data available
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation was observed.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The substance p-tolyl acetate (CAS No.140-39-6) when administered to rabbits by the dermal route, is to be considered ―non-irritant for the skin.
Executive summary:

Skin irritation potentials of p-tolyl acetate (CAS No. 140-39-9) were investigated in rabbits. p-tolyl acetate (CAS No.140-39-6) applied full strength on intact or abraded rabbit skin and effects were observed (duration not specified), produced no skin irritation. Hence, p-tolyl acetate (CAS No.140-39-6) was classified as non-irritating to skin.