5-(1-methylpiperidin-4-yl)-5H-dibenzo[a,d][7]annulen-5-ol

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: screening tests

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

2014

Materials and methods

Principles of method if other than guideline:

The ready biodegradability was estimated by using BIOWIN, Toxtree and Vega predictors.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(1-methylpiperidin-4-yl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaen-2-ol

EC Number:

609-737-8

Cas Number:

3967-32-6

Molecular formula:

C21H23NO

IUPAC Name:

2-(1-methylpiperidin-4-yl)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaen-2-ol

Results and discussion

% Degradation

Remarks on result:

other: Not ready biodegradable (Reliable)

Applicant's summary and conclusion

Conclusions:

Ready biodegradability for the target 5-(1-methylpiperidin-4-yl)-5H-dibenzo[a,d][7]annulen-5-ol was estimated by using three predictors: BIOWIN, Toxtree and Vega. The three predictors were employed in order to apply a consensus approach to enhance the reliability of the prediction. In the consensus assessment only reliable predictions are to be taken into account. Although, BIOWIN and Toxtree did not provide a detailed assessment of their reliability, and Vega prediction was not reliable, the three tools were in agreement leading to the consensus prediction of NOT READILY BIODEGRADABLE.