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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from GSBL

Data source

Reference
Reference Type:
secondary source
Title:
Range-Finding Toxicity Data, List V
Author:
GSBL
Year:
1996
Bibliographic source:
German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Hexylamine in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexylamine
EC Number:
203-851-8
EC Name:
Hexylamine
Cas Number:
111-26-2
Molecular formula:
C6H15N
IUPAC Name:
hexan-1-amine
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): Hexylamine
- Molecular formula (if other than submission substance): C6H15N
- Molecular weight (if other than submission substance): 101.191 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Weight at study initiation: 90-120g
Fasting period before study: Not fasted before dosing

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
VEHICLE
Concentration in vehicle: 25% in water
Amount of vehicle (if gavage):between 1 -10ml
Justification for choice of vehicle: an aqueous solution of 25% Na 3,9-diethyl6-tridecanolsulfat was dissolved in water, corn oil or 1% Tergitol 7 Penetrant dissolved.
Doses:
No data
No. of animals per sex per dose:
5 male
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?): 14 days
Statistics:
LD50 value and range of confidence were determined by the Thompson method (Bacteriol Rev. 11, 1947, p. 115) using the tables of Weil (Biometrics 8, 1952, p 249).

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
670 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in treated male rats.
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.
Executive summary:

In a acute oral toxicity study, Wistar male rats by using Hexylamine orally by gavage and observed for 14 days. 50 % mortality was observed in treated male rats at 670 mg/kg bw. Therefore, LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.