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Diss Factsheets
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EC number: 942-466-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1998-08-03 - 199-02-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study conducted with valid source substance. For detailed justification of the read-across procedure, please refer to the separate statement by Chemservice S.A. (2013).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of The United Kingdom
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- Not applicable.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
- Physical state: Extremely pale yellow straw coloured viscous liquid
- Storage conditions: Room temperature, in darkness
Study design
- Test temperature:
- 30 °C
HPLC method
- Details on study design: HPLC method:
- PREPARATION OF SAMPLE SOLUTION
1.9940 g of test substance was diluted to 100 mL with methanol.
PREPARATION OF REFERENCE SOLUTIONS
The dead time was determined by measuring the retention time of formamide (purity 99.5 %, 1.14 x 10E3 mg/L) solution in methanol.
Acetanilide, phenol, atrazine, isoproturon, naphthalene, fenthion, alpha endosulfan, pyrazophos, phenanthrene, diclofop-methyl and DDT served as reference standards and were prepared in methanol.
HPLC PARAMETERS
- System: Hewlett-Packard 1050, incorporating autosampler and workstation
- Column: Hypersil 5µ CN BDS (250 mm x 4.6 mm id)
- Column temperature: 30 °C
- Mobile phase: methanol:water (55:45 v/v)
- pH of mobile phase: 5.9
- Flow rate: 1.0 mL/min
- UV detector wavelength: 210 nm
- Injection volume: 10 µL
CALCULATION OF CAPACITY FACTORS (k)
k = tr - t0 / t0
whereby:
k - capacity factor
tr - retention time [min]
t0 - dead time [min]
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- 1.25 - 3.69
- Temp.:
- 30 °C
- Type:
- Koc
- Value:
- 17.8 - 4 930
- Temp.:
- 30 °C
Results: HPLC method
- Details on results (HPLC method):
- The measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However the dissociation constants of the test substance are outside the environmental pH range required for this test (it is also not practical to employ such low pH (~3) or high pH (~12) in the test); since adjustment was not environmentally relevant or experimentally practical, measurement was carried out on the ionised form only.
A calculated value of adsorption coefficient was derived for each whole salt using a computer-based atom fragment contribution method. The result was logKoc = 4.3 and 6.2.
The components of the test substance were also considered and calculated individually. The two acid components gave logKoc values of 1.9 and 3.9, and the amine component gave a logKoc of 2.8.
Any other information on results incl. tables
Table 2. Retention times of formamide and reference standards
Standard |
Retention time [min] |
Mean retention time [min] |
|
Injection 1 |
Injection 2 |
||
Formamide (dead time) |
3.235 |
3.234 |
3.235 |
Acetanilide |
3.627 |
3.627 |
3.627 |
Phenol |
3.583 |
3.580 |
3.582 |
Atrazine |
3.991 |
3.992 |
3.992 |
Isoproturon |
4.188 |
4.188 |
4.188 |
Naphthalene |
4.967 |
4.964 |
4.966 |
Fenthion |
6.307 |
6.309 |
6.308 |
Alpha endosulfan |
8.811 |
8.814 |
8.813 |
Pyrazophos |
6.698 |
6.699 |
6.699 |
Phenanthrene |
8.337 |
8.309 |
8.323 |
Diclofop-methyl |
8.657 |
8.645 |
8.651 |
DDT |
19.294 |
19.267 |
19.281 |
Table 3. Capacity factor (k), logk and logKoc for the reference standards
Standard |
Capacity factor (k) |
logk |
logKoc |
Acetanilide |
0.121 |
-0.916 |
1.25 |
Phenol |
0.107 |
-0.969 |
1.32 |
Atrazine |
0.234 |
-0.631 |
1.81 |
Isoproturon |
0.295 |
-0.530 |
1.86 |
Naphthalene |
0.535 |
-0.272 |
2.75 |
Fenthion |
0.950 |
-2.217 x 10E-2 |
3.31 |
Alpha endosulfan |
1.725 |
0.237 |
4.09 |
Pyrazophos |
1.071 |
2.977 x 10E-2 |
3.65 |
Phenanthrene |
1.573 |
0.197 |
4.09 |
Diclofop-methyl |
1.675 |
0.224 |
4.20 |
DDT |
4.961 |
0.696 |
5.63 |
Table 4. Retention time, capacity factors and logKoc for the sample
Component |
Injection |
Retention times [min] |
Capacity factor (k) |
logk |
logKoc |
First |
1 |
2.658 |
-0.178 |
- |
< 1.25 |
2 |
2.344 |
-0.275 |
- |
||
Final |
1 |
6.840 |
1.115 |
4.716 x 10E-2 |
3.69 |
2 |
6.860 |
1.121 |
4.956 x 10E-2 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Validity criteria of the applied guideline were fulfilled.
- Conclusions:
- The study report describes a valid guideline study conducted under certificated GLP compliance. The adsorption coefficient has been determined to be in the range < 17.8 - 4.93 x 10E3 with a corresponding logKoc range of < 1.25 - 3.69.
- Executive summary:
The determination of the adsorption coefficient was carried out using the High Performance Liquid Chromatography (HPLC) screening method specified in the draft of the OECD Guideline 121 (Lumsden, 1999). The test substance was diluted with methanol. The dead time was determined using formamide and acetanilide, phenol, atrazine, isoproturon, naphthalene, fenthion, alpha endosulfan, pyrazophos, phenanthrene, diclofop-methyl and DDT served as reference standards. The temperature was set at 30 °C and the pH of the mobile phase was measured as 5.9. The measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However the dissociation constants of the test substance are outside the environmental pH range required for this test (it is also not practical to employ such low pH (~3) or high pH (~12) in the test); since adjustment was not environmentally relevant or experimentally practical, measurement was carried out on the ionised form only. A calculated value of adsorption coefficient was derived for each whole salt using a computer-based atom fragment contribution method. The result was logKoc = 4.3 and 6.2. The components of the test substance were also considered and calculated individually. The two acid components gave logKoc values of 1.9 and 3.9, and the amine component gave a logKoc of 2.8. The overall logKoc is in the range < 1.25 - 3.69. The adsorption coefficient (Koc) is therefore in the range < 17.8 - 4.93 x 10E3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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