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EC number: 210-695-4 | CAS number: 621-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- For the assessment of ethane, 2-chloro-1,1-diethoxy (chloroacetaldehyde-diethylacetal) a read-across approach to the structural analogue ethane, 2-chloro-1,1-dimethoxy (chloroacetaldehyde-dimethylacetal) has been considered appropriate as both substances have similar physical-chemical properties. The dimethylacetal can be considered as a worst-case-approach as it has a lower molecular weight compared with the diethylacetal. The dimethylacetal has a lower pH in water, a higher water solubility, a higher vapour pressure, boiling point and flammability. Stability and hydrolysis are also comparable with ethane, 2-chloro-1,1-diethoxy resp. ethane, 2-chloro-1,1-dimethoxy reacting with acids releasing chloroacetaldehyde and ethanol resp. methanol. Here also the release of methanol can be - compared to the release of ethanol - considered as a worst-case approach.
Therefore the read-across from the diethoxy-compound to the dimethoxy-compound is considered appropriate.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD Guideline Study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (U.K.) Limited, Manston, Kent
- Age at study initiation: 5-6 weeks
- Weight at study initiation: males 188-222g, females 153-184g
- Housing: polypropylene grid-floor cages suspended over trays containing absorbent paper
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22°C
- Humidity (%): 48-59%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 50, 250, 500 mg/kg BW
- No. of animals per sex per dose:
- 3/sex/dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: day 1, 4, 8, 11 and 14
- Necropsy of survivors performed: yes: All decedents and animals killed on day 15 were subjected to a full macroscopic, internal and external examination
- Other examinations performed: twice daily for 14 days for overt signs of toxicity, ill health or behavioural change
- concentrations: 0, 50, 250, 500 mg/kg/day - Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: none
- Mortality:
- One male treated with 500 mg/kg/day was found dead on day 2, the remaining males were killed in extremis at the end of the working
day. Due to the severe nature of the observations detected in one female the following morning, the animal was killed in extremis.
The remaining two females were also killed in extremis after the 1 hour observations had been performed. One male from the 250 mg/kg/day dose group was found dead on day 3. There were no deaths in the 50 mg/kg/day dose group. - Clinical signs:
- no abnormalities in control group and 50mg/kg/day group.
250 mg/kg/day: Lethargy, Ataxia, Death, increased salivation immediatley after dosing, increased salviation, wet fur, red/brown staining around mouth
500 mg/kg/day: increased salivation immediatley after dosing, hunched posture, Lethargy, Pilo-erection, Extreme Lethargy, Decreased respiration rate, Increased salivation, Ataxia, Pallor of the extremities, Chromodacryorrhoea, Dehydration, Death - Body weight:
- 250 mg/kg/day: slight reduction in body weight gain
50 mg/kg/day: body weight gain was comparable with that seen in controls - Other findings:
- Necropsy:
500 mg/kg/day: animal found dead on day 2 showed macroscopic abnormalities consistent with normal post mortem changes. These included dark lungs, liver and kidneys, sloughing of the glandular gastric epithelium and congestion of the small intestine. Further abnormalities detected in the animals killed in extremis included pale spleen, pale kidneys, pallor or patchy pallor of the liver, with one animal showing accentuated lobular pattern, yellow staining or ulceration of the glandular gastric epithelium, gaseous distension of the stomach and congestion of the small intestine.
250 mg/kg/day: dark liver and kidneys and gaseous distension of the stomach. One female also showed a reddened glandular gastric epithelium at necropsy.
50 mg/kg/day: no macroscopic abnormalities were detected - Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dose levels for the main twenty-eight day study were chosen as:
High dose: 200 mg/kg/day
Intermediate dose: 50 mg/kg/day
Low dose :15 mg/kg/day
- plus a control group treated with vehicle only - Executive summary:
To establish the maximum tolerated dose level (up to 1000 mg/kg/day) of the test material Chloroacetaldehyde dimethylacetal equivalent to OECD Guideline 401 following repeated oral administration to the Sprague-Dawley CD strain rat, and to establish a low dose level that does not produce evidence of toxicity. This information will be used to determine dose levels for use in a twenty-eight day oral toxicity study. This study can be found in appendix XIII in the test report "28 Day sub-acute oral toxicity study in the rat"
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- IUPAC Name:
- Ethane, 2-Chloro-1,1-Dimethoxy-
- Reference substance name:
- 97-97-02
- IUPAC Name:
- 97-97-02
- Reference substance name:
- 2-chloro-1,1-dimethoxyethane
- EC Number:
- 202-624-0
- EC Name:
- 2-chloro-1,1-dimethoxyethane
- Cas Number:
- 97-97-2
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-chloro-1,1-dimethoxyethane
- Test material form:
- other: colourless liquid
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetaldehyde dimethylacetal
- Physical state: colourless liquid
- Storage condition of test material: room temperature
- Container: brown glass bottle x2
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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