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Diss Factsheets
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EC number: 223-358-1 | CAS number: 3852-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent GLP study according to OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methyl 3-methoxypropionate
- EC Number:
- 223-358-1
- EC Name:
- Methyl 3-methoxypropionate
- Cas Number:
- 3852-09-3
- Molecular formula:
- C5H10O3
- IUPAC Name:
- methyl 3-methoxypropanoate
- Details on test material:
- - Lot/batch No.: M50623Y02
- Storage condition of test material: at room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Preliminary range-finding: National Institute of Public Health, 1097 Budapest Gyáli u. 2-6 Hungary, Main: Szent István University, Department of Aquaculture, 2100 Gödöllő, Páter Károly u. 1. – Hungary
- Age at study initiation: < 24 h at beginning of the test
- Feeding during test: no
ACCLIMATION
- Acclimation period: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- control: 20.1-20.3 °C
100 mg/l: 20.1-20.3 °C - pH:
- control: 7.30-7.37
100 mg/l: 7.33-7.40 - Dissolved oxygen:
- control: 8.2-8.3 mg/l
100 mg/l: 8.1-8.1 mg/l - Nominal and measured concentrations:
- nominal: 100 mg/l
measured: at the start: 96.7 mg/l, at the end: 82.5 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water (ISO medium)
OTHER TEST CONDITIONS
- Photoperiod: 16 h light/8 h dark
TEST CONCENTRATIONS
- Range finding study: 0.1, 1, 10, 100 mg/l - Reference substance (positive control):
- yes
- Remarks:
- Not concurrent, potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Results with reference substance (positive control):
- - EC50 (24 h): 1.16 mg/l (95% CL: 1.07-1.25 mg/l)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- No immobility observed in the control group and dissolved oxygen at the end of the test was > 8 mg/l
- Executive summary:
Because no toxic response was observed during the preliminary range-finding test, only a limit test was carried out using only one test concentration (100 mg/l) and one control group in the main study in a static system.
The test concentration was analytically determined at the start and at the end of the experiment. The measured concentration was 96.7 and 82.5 mg/l at the end of the experiment.
No immobility nor abnormal behavior of test animals was observed.
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