Registration Dossier
Registration Dossier
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EC number: 224-208-8 | CAS number: 4247-02-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames (OECD 471): not mutagenic in S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and E. coli WP2 uvr A with and without metabolic activation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Mutagenic activity of isobutyl 4-hydroxyparaben was investigated in a bacterial reverse mutation assay (Ames test; test strains used: S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and E. coli WP2 uvr A (Verbaan, 2016).Test concentrations up to 1,600 µg/plate were tested in the experiment. The test compound proved to be not mutagenic to the bacterial strains.
Justification for classification or non-classification
The available data on genetic toxicity do not meet the criteria for classification according to Regulation (EC) 1272/2008.
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