Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 81% in 28 days (OECD 301F)
Key value for chemical safety assessment
Additional information
The ready biodegradability of Diisooctadecyl malate (CAS 67763-18-2) was tested in a GLP guideline study following OECD 301F (Simon, 2015). Due to the low water solubility of the substance two test approaches with different test substance concentrations were conducted. In the first approach the biodegradation rate at a substance concentration of 100 mg/L test substance was tested. In the second approach the substance concentration was reduced to 20 mg/L. The degradation rate was investigated by measuring the oxygen demand of the inoculum (activated sludge). After 28 days, the test substance reached 53% biodegradation in the assays with a concentration of 100 mg test substance/L. The ten day window criterion was not met. The second assay with 20 mg test substance/L reached 81% degradation after 28 days. The ten day window was met. The degradation of substances with low water solubility and a high ThOD can be deferred at high substance concentrations. Thus the degradation rate at a substance concentration of 20 mg/L is considered reliable and Diisooctadecyl malate (CAS 67763-18-2) is considered to be readily biodegradable according to OECD criteria.
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