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EC number: 251-974-0 | CAS number: 34375-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis
Aqueous hydrolysis of test chemical 2-(hydroxymethylamino)ethanol (CAS no. 34375 -28 -5) was carried out for 30 days at pH 5, 7 and 9, respectively (HPV Chemical Challenge Program, 2016). Since radioactively labeled material was not available for the study, the 95% grade compound was used and chemical analysis was used to identify the breakdown products. The initial amount of test material dissolved in the buffers was 250 µg/ml. The buffers were autoclaved after preparation and before the test substance was added. Efforts were made to maintain sterility. For the duration of the study, the solutions were maintained in darkness in a water bath adjusted to 25°C. The temperature of the bath was recorded once daily, with an average of 25°C, ranging from 24.9 to 25.1°C. The solutions were sampled for immediate chromatographic analysis at intervals of 0, 1, 3, 7, 14, 21 and 30 days. Samples from each time point were also placed in the freezer for further analysis. Liquid chromatographic analysis of the fresh samples using post-column detection allowed quantitation of primary amines. There was immediate, or nearly immediate hydrolysis of Troysan at pH 5.0, 7.0 and 9.0 at 25°C. The hydrolysis of Troysan 174 to formaldehyde and ethanolamine was too rapid to be quantified. The recovery of 2 degradation substances together after 30 days (calculated as a percentage of the initial, using Troysan 174 dissolved in water as the standard) averaged 91.5% at pH 5, 97.5% at pH 7 and 97.1% at pH 9, respectively. Formaldehyde and ethanolamine was the breakdown product of the test chemical 2 -(hydroxymethylamino)ethanol.
Additional information
Hydrolysis
Aqueous hydrolysis of test chemical 2-(hydroxymethylamino)ethanol (CAS no. 34375 -28 -5) was carried out for 30 days at pH 5, 7 and 9, respectively (HPV Chemical Challenge Program, 2016). Since radioactively labeled material was not available for the study, the 95% grade compound was used and chemical analysis was used to identify the breakdown products. The initial amount of test material dissolved in the buffers was 250 µg/ml. The buffers were autoclaved after preparation and before the test substance was added. Efforts were made to maintain sterility. For the duration of the study, the solutions were maintained in darkness in a water bath adjusted to 25°C. The temperature of the bath was recorded once daily, with an average of 25°C, ranging from 24.9 to 25.1°C. The solutions were sampled for immediate chromatographic analysis at intervals of 0, 1, 3, 7, 14, 21 and 30 days. Samples from each time point were also placed in the freezer for further analysis. Liquid chromatographic analysis of the fresh samples using post-column detection allowed quantitation of primary amines. There was immediate, or nearly immediate hydrolysis of Troysan at pH 5.0, 7.0 and 9.0 at 25°C. The hydrolysis of Troysan 174 to formaldehyde and ethanolamine was too rapid to be quantified. The recovery of 2 degradation substances together after 30 days (calculated as a percentage of the initial, using Troysan 174 dissolved in water as the standard) averaged 91.5% at pH 5, 97.5% at pH 7 and 97.1% at pH 9, respectively. Formaldehyde and ethanolamine was the breakdown product of the test chemical 2 -(hydroxymethylamino)ethanol.
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