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EC number: 812-739-3 | CAS number: 157357-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From June 13 to June 27, 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP study conducted according to OECD test Guideline No. 402. The study was fully reliable (Klimisch score = 1), however the reliability score was lowered to 2 which is the maximum score for read-across. The supporting substance is considered adequate for read-across purpose (see IUCLID section 13 for additional justification). The ennvironmental conditions were not reported but assumed to be adequate because it is a GLP study.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Environmental conditions not reported, but GLP study so assumed to be adequate.
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-pentylcyclopentan-1-ol
- EC Number:
- 283-187-3
- EC Name:
- 2-pentylcyclopentan-1-ol
- Cas Number:
- 84560-00-9
- IUPAC Name:
- 2-pentylcyclopentanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): ST 22 C 95
- Physical state: clear liquid
- Storage conditions: ambient temperature in the container in which it was received
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Trevanor Farm, Mainesburg, PA. USDA # 23-A-055.
- Age at study initiation: no data.
- Weight at study initiation: 2-3 kg bw
- Housing: individually housed in suspended stainless steel wire-mesh cages.
- Diet: Agway Prolab High Fiber Rabbit feed and Alfalfa cubes, ad libitum.
- Water: city water ad libitum.
- Acclimation period: at least 7 days.
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- % coverage: 10%
- Type of wrap if used: 15 cm² porous gauze patch overwrapped with a gauze strip and held in place with Elastikon tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, no details
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Dose volume = [Animal Weight (kg) x Limit Dose (2 g/kg)] / density (0.91 g/mL).
- Constant volume or concentration used: no - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily, 7 days a week. Observations included the following: skin and fur, and eyes and mucous membranes, circulatory, autonomic and central nervous systems and behaviour patterns.
- Necropsy of survivors performed: yes, gross necropsy after sacrifice by sodium pentobarbital.
- Other examinations performed: body weight, recorded just prior to administration and on day 7 and 14. - Statistics:
- none
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality.
- Clinical signs:
- other: No clinical observations.
- Gross pathology:
- No gross abnormalities.
- Other findings:
- Dermal observation: on day 1, 5/5 females and 5/5 males had well-defined erythema. 3 females and 1 male had well-defined oedema; 2 females and 3 males had very slight oedema; 1 male had no oedema. On day 7, all animals had very slight erythema with flaking skin. There was no oedema noted. On day 14, there was no erythema or oedema noted. However, 4 females and the 5 males had flaked skin.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal LD50 Combined > 2000 mg/kg bw
- Executive summary:
In a limit acute dermal toxicity study performed according to the OECD guideline No. 402, groups of New Zealand White rabbit (5/sex)were semi-occlusively exposed to undiluted test material for 24 hours to 10% of the body surface at dose of 2000 mg/kg bw. The animals were observed for mortality, clinical signs including dermal reactions and body weight for 14 days and then necropsied for macroscopic observations.
No mortality occurred during the study. There were no signs of systemic reaction to treatment. No abnormality was revealed at autopsy. On day 1, erythema and oedema (score 2) were observed in all animals. On day 7, all animals had very slight erythema with flaking skin. There was no oedema noted. On day 14, there was no erythema or oedema noted. However, 4 females and the 5 males had flaked skin.
Dermal LD50Combined > 2000 mg/kg bw
Under the test conditions, the test material is not classified according to the annex VI of the Regulation EC No. 1272/2008 (CLP).
This study is considered as acceptable and satisfies the requirement for acute dermal toxicity endpoint.
The supporting substance is considered adequate for read-across purpose (see IUCLID section 13 for justification).
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