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Diss Factsheets
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EC number: 257-768-7 | CAS number: 52236-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- Justification for Read Across is reported in the endpoint summary and it is further detailed in the report attached to the IUCLID section 13.
- Principles of method if other than guideline:
- Internal method Nr. 11.
The acute fish toxicity test was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1981. These methods were comparable to current standard testing procedure
published by the OECD within Guideline for Testing of Chemicals 203: Fish, Acute Toxicity Test, adopted by the Council on 17th July 1992. - GLP compliance:
- no
- Remarks:
- pre GLP
- Test organisms (species):
- Salmo sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout.
- Supplier: P. Hohler, 4314 Zeiningen.
- Age at study initiation: about 4 - 6 months.
- Length at study initiation: 4 - 8 cm
- Weight at study initiation: 3 - 6 g
- Feed: daily (TETRA MIN, flocks, Dr. U.Baersch GmbH, D-4520 Melle, Germany).
ACCLIMATION
- Acclimation period: minimum 12 days.
- Acclimation conditions: temperature of 10-13 °C. - Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 12 °C
- pH:
- 8 - 8.2
- Dissolved oxygen:
- O2-concentration was be kept at 4.8 mg/l at a minimum. Sufficient oxygen supply was ensured. O2-target concentration 6.4 mg/l
- Nominal and measured concentrations:
- Nominal concentrations: 100, 200, 1000 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: full-glass basins, 17 liters basis (36x23x26 cm) tempered (cold-room), filled by 15 liters.
- No. of organisms per concentration: 8 per test concentration.
TEST MEDIUM / WATER PARAMETERS
- Dilution water: water used according to ISO guidelines.
- Preparation: 7.5 ml of each one of the stock-solutions 1 and 2 and 75 ml of stock-solution 3, add 15 liter of deionized water.
Stock-solution 1: 250 g CaCl x 2 H2O, 29 g NaCl, 9 g NaNO3, add 1 liter of deionized water
Stock-solution 2: 115 g MgSO x 7 H2O, 79 g Na2SO4, add 1 liter of deionized water.
Stock-solution 3: 27 g NaHO3, add 1 liter of deionized water. - Duration:
- 48 h
- Dose descriptor:
- other: TL50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No deaths occurred.
- Sublethal observations / clinical signs:
Conc. (mg/l) Survivors pH at 48 hrs 24hrs 48hrs 100 8 8 8.1 200 8 8 8.2 1000 8 8 8 - Conclusions:
- TL50 (48h) > 1000 mg/l (nominal)
- Executive summary:
Method
The acute fish toxicity test was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1981. These methods were comparable to current standard testing procedure published by the OECD within Guideline for Testing of Chemicals 203: Fish, Acute Toxicity Test, adopted by the Council on 17th July 1992. Eight trouts per concentration were exposed at 100, 200 and 1000 mg test item/l, over a period of 48 hours.
Results
At the end of the experiment, no death was recorded, thus TLC50 (48h) resulted to be higher than 1000 (nominal).
Reference
Description of key information
Non harmful/toxic to fish, short-term exposure
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 613 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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