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EC number: 202-085-1 | CAS number: 91-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance show signs of skin and eye irritation in test on animals.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion:
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Marhold et all, Prehled Prumyslove Toxikologie; Organicke Latky. Avicenum, Prague, Czechoslovakia, 1986 when 2-methylquinoline was tested on rabbit skin at 500 mg for 24 hours mild irritation was observed. To confirm this effect in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 is reported also a study on coal tar, which contains 0.6% to 4.2% of 2-methylquinoline: coal tar caused thickness in guinea-pig epidermis (Sarkany and Gaylarde, Clin. Exp. Dermatol. 1/1:51-58, 1976)
Eye irritation/corrosion:
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 2 -methylquinoline caused severe eye irritation in rabbits at a dose of 750 μg. The reference mentioned by NTP, 2002 in not found using the link indicated but a report of BCOP test on different compounds is published on NTP website (see http://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/ocubrd/bcop/bcop7.pdf, document BCOP BRD: Section 7-March2006). In this document the results of Intralaboratory CV Analysis of BCOP performed in 1998 for different compounds were reported: for 2-methylquinoline the BCOP test gave a IVIS = 25.5 with an in vitro prediction of moderate eye irritation.
According to OECD 437, with 3 <IVIS≤ 55 no prediction should be done regarding eye irritation. Based on precautionary principle(IVIS is not less than 3 and so it is not possible exclude skin irritation) and considering that eyes generally are more sensitive than skin and from experimental study the substance is skin irritant, 2-methylquinoline should be considered reasonably eye irritant.
Justification for selection of skin irritation / corrosion endpoint:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Justification for selection of eye irritation endpoint:
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the results from experimental studies (mild irritation after application of the substance on rabbit skin and IVIS of BCOP test = 25,5) and considering that eyes generally are more sensitive than skin the classification proposed for the substance is irritant for skin (H315: skin irritation/corrosion cat.2) and irritant for eye (H319: Eye damage/eye irritation cat.2) according to CLP Regulation (EC n.1272/2008).
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