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EC number: 200-625-0 | CAS number: 66-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative source
Data source
Reference
- Reference Type:
- publication
- Title:
- IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
- Author:
- World Health Organization
- Year:
- 1 999
- Bibliographic source:
- IARC Monograph. World Health Organization, International Agency for Research on Cancer, V71 1072 (1999)
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Details of guidelines not mentioned in the publication
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl methanesulphonate
- EC Number:
- 200-625-0
- EC Name:
- Methyl methanesulphonate
- Cas Number:
- 66-27-3
- Molecular formula:
- C2H6O3S
- IUPAC Name:
- methyl methanesulfonate
- Test material form:
- other: Liquid
- Details on test material:
- CAS NO: 66-27-3
Chemical Name: Methyl methanesulfonate
Nature of chemical: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Methyl methanesulfonate (MMS)
- Molecular formula: C2H6O3S
- Molecular weight: 110.1324 g/mole
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- yes
- Remarks:
- [methyl-14C] methyl methanesulfonate 30 %
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Details on exposure:
- Rats were injected with [methyl-14C]methyl methanesulfonate
- Duration and frequency of treatment / exposure:
- Monitring period mentioned in the publication is 30 hrs
Doses / concentrations
- Dose / conc.:
- 100 mg/kg bw/day
- No. of animals per sex per dose / concentration:
- not specified
- Control animals:
- not specified
- Positive control reference chemical:
- not specified
- Details on study design:
- not specified
- Details on dosing and sampling:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary studies:
- not specified
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- [methyl-14C] methyl methanesulfonate is likely to be absorbed after intravenous injection since it is then rapidly distributed to other body parts.
- Type:
- distribution
- Results:
- The chemical is rapidly distributed throughout the body of rats, including the central nervous system, and rapidly crosses the placenta. After intravenous injection of 100 mg/kg bw methyl methanesulfonate to rats none was detected in serum after 2 h.
- Type:
- metabolism
- Results:
- Glutathione conjugation has been shown to occur in rat liver. Metabolites resulted from initial methylation of cysteine residues by methyl methanesulfonate.
- Type:
- excretion
- Results:
- In rats injected with [methyl-14C]methyl methanesulfonate, about 30% of the label was exhaled as CO2 within 30 h. Urinary metabolites recovered within the first 16 h represented 80% of the excretion products.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not specified
- Details on distribution in tissues:
- not specified
- Details on excretion:
- not specified
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Methylmercapturic acid sulfoxide, 2-hydroxy-3-methylsulfinylpropionic acid, methylsulfinylacetic acid, methylmercapturic acid and N-(methylthioacetyl) glycine.
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
When rats were injected with [methyl-14C]methyl methanesulfonate, the chemical was rapidly distributed to various body parts of the rats including the central nervous system, and also crosses the placenta. However, the chemical is metabolized to various metabolites that constitute 80% of the of the excretion products. 30% of the label was exhaled as CO2 within 30 h. Thus, considering that the chemical is metabolized and excreted out of the body of the rats in less than 2 days, the chemical is expected to have low bio-accumulation potential. - Executive summary:
There is no information available pertaining to the toxico-kinetics ofMethyl methanesulphonate in humans. Information available from in vivo study conducted in rats (strain not specified), indicates that the radiolabeled[methyl-14C]methyl methanesulfonate is rapidly distributed to the various body parts of the rats after intravenous injection. It is metabolized into various breakdown products that are dominantly excreted (80%) in urine within the first 16 hours. About 30% of the label was exhaled as CO2within 30 h.
Thus, from the above, it can be concluded that the chemicalMethyl methanesulphonate is expected to have “low bio-accumulation potential” within the body of rats.
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