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EC number: 210-441-2 | CAS number: 615-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation
In a skin irritation test in rabbits with 0.5 ml, 2.5%w/v 2-chloro-p-phenylenediamine in distilled water , no irritation was observed after 24 and 72 hours of observation period. Thus, the test chemical 2-chloro-p-phenylenediamine can be judged as a non irritant.
Eye Irritation
The substance 2-chloro-p-phenylenediamine is non-irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The skin irritation study was conducted on albino rabbits to assess the irritation potential of 2-chloro-p-phenylenediamine.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-chloro-p-phenylenediamine
- Molecular formula: C6H7N2Cl
- Molecular weight: 142.588 g/mol
- Substance type: Organic
- Physical state: Solid
- Purity: 99%
- Impurities (identity and concentrations):1 % - Species:
- rabbit
- Strain:
- not specified
- Remarks:
- Albino
- Details on test animals or test system and environmental conditions:
- Albino rabbits were used for the study.
- Type of coverage:
- other: Patch tests
- Preparation of test site:
- other: one intact and one abraded site
- Vehicle:
- water
- Remarks:
- Distilled water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml of 2.5% w/v 2-chloro-p-phenylenediamine in distilled water.
- Observation period:
- 24 hours and 72 hours
- Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: one intact and one abraded site on the dorsum
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available
SCORING SYSTEM: After 24 hours of exposure, the patches were removed and the test sites scored on a scale of 0 to 4 (CFR, Title 16, Section 1500.41). Sites were scored again 72 h after the application. - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: No observable response were observed
- Irritant / corrosive response data:
- None of the animals showed any observable response to treatment throughout the 72 hours observation period.
- Interpretation of results:
- other: not irritating based on CLP criteria
- Conclusions:
- In a skin irritation test in rabbits with 0.5 ml, 2.5%w/v 2-chloro-p-phenylenediamine in distilled water , no irritation was observed after 24 and 72 hours of observation period.
Thus, the test chemical 2-chloro-p-phenylenediamine can be judged as a non irritant. - Executive summary:
The skin irritation study was conducted on albino rabbits to assess the irritation potential of the test compound 2-chloro-p-phenylenediamine. 3 albino rabbits were clipped free of hair. A patch with 0.5 ml of 2.5% w/v 2-chloro-p-phenylenediamine in distilled water was applied to both one abraded and one intact site on each animal. After 24 hours of exposure, the patches were removed and the test sites scored on a scale of 0 to 4 (CFR, Title 16, Section 1500.41). Sites were scored again 72 h after the application. None of the animals showed any observable response to treatment throughout the 72 hours observation period. Thus, based on the study 2-chloro-p-phenylenediamine (CAS No: 615-66-7) is not considered to be an irritant to rabbit skin and being classified as "not classified" as per CLP regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Eye irritation study was conducted on rabbits to evaluate the irritation potential of the test compound 2-chloro-p-phenylenediamine (CAS No.- 615 -66-7).
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):2-chloro-p-phenylenediamine
- Molecular formula:C6-H7-Cl-N2
- Molecular weight:142.588 g/mole
- Substance type:Organic
- Physical state:Solid
- Purity: 99%
- Impurities (identity and concentrations): 1 % - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- water
- Remarks:
- Water buffered to pH 7 with 0.05% sodium sulfite
- Controls:
- not specified
- Amount / concentration applied:
- 2.5 % (w/v)
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: Eye
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Eyes were rinsed with 20 mL of distilled water.
- Time after start of exposure: Ten seconds
SCORING SYSTEM: No data available - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: non-irritating
- Irritant / corrosive response data:
- One animal showed mild conjunctival inflammation. Two animals did not show any observable response to treatment throughout the 7 days observa tion period.
- Interpretation of results:
- other: not irritating based on CLP criteria
- Conclusions:
- The substance 2-chloro-p-phenylenediamine is non-irritating to the eyes of rabbits.
- Executive summary:
Eye irritation study was conducted on 3 rabbits to evaluate the irritation potential of the test compound 2-chloro-p-phenylenediamine (CAS No.- 615 -66 -7). 2.5% (w/v) 2-chloro-p-phenylenediamine in water (pH 7) was instilled into one eye of each of the three rabbits. Ten seconds after instillation the eyes were rinsed with 20 mL of distilled water.
In one animal mild conjunctival inflammation was observed. Two animals did not show any observable response to treatment throughout the 7 days observati on period.
2-chloro-p-phenylenediamine is non-irritating to the eyes of rabbits and being classified as "not classified" as per CLP regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
The test compound 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was investigated for its dermal irritation potential to a greater or lesser extent. Often are the studies based on in vivo experiment and estimated data in rodents, i.e. most commonly in rabbits for 2-chloro-p-phenylenediamine. The predicted data using the OECD QSAR toolbox has also been compared with the experimental data. The studies are summarized as below:
The skin irritation study was conducted by Lynn Willis (Journal Of The American College Of Toxicology Volume 11, Number 4,1992) on albino rabbits to assess the irritation potential of the test compound 2-chloro-p-phenylenediamine. 3 albino rabbits were clipped free of hair. A patch with 0.5 ml of 2.5% w/v 2-chloro-p-phenylenediamine in distilled water was applied to both one abraded and one intact site on each animal. After 24 hours of exposure, the patches were removed and the test sites scored on a scale of 0 to 4 (CFR, Title 16, Section 1500.41). Sites were scored again 72 h after the application. None of the animals showed any observable response to treatment throughout the 72 hours observation period. Thus, based on the study 2-chloro-p-phenylenediamine (CAS No: 615-66-7) is not considered to be an irritant to rabbit skin.
Moreover, the skin irritation potential of 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was estimated using OECD QSAR toolbox version 3.3 with log Kow as the primary descriptor. The substance 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was estimated to be not irritating to the skin of New Zealand White rabbits.
Thus, on the basis of the above studies for the target substance, it was concluded that 2-chloro-p-phenylenediam ine (CAS No: 615-66-7) was considered to be not irritating to the skin and being classified as “Not Classified” as per CLP Regulation.
Eye irritation
The test compound 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was investigated for its ocular irritation potential to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits for 2-chloro-p-phenylenediamine. The predicted data using the OECD QSAR toolbox has also been compared with the experimental data. The studies are summarized as below:
Eye irritation study was conducted by Lynn Willis (Journal Of The American College Of Toxicology Volume 11, Number 4,1992) on 3 rabbits to evaluate the irritation potential of the test compound 2-chloro-p-phenylenediamine (CAS No.- 615 -66 -7). 2.5% (w/v) 2-chloro-p-phenylenediamine in water (pH 7) was instilled into one eye of each of the three rabbits. Ten seconds after instillation the eyes were rinsed with 20 mL of distilled water. In one animal mild conjunctival inflammation was observed. Two animals did not show any observable response to treatment throughout the 7 days observati on peri od. Thus, based on the study 2-chloro-p-phenylenediamine is non-irritating to the eyes of rabbits.
Moreover, the ocular irritation potential of 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was estimated using OECD QSAR toolbox version 3.3 with log Kow as the primary descriptor. 2-chloro-p-phenylenediamine (CAS No: 615-66-7) was estimated to be not irritating to the eyes of albino rabbits.
Thus, on the basis of the above studies for the target substance, it was concluded that 2-chloro-p-phenylenediami ne (CAS No: 615-66-7) was not considered to be an irritant to eyes and being classified as “Not Classified” as per CLP Regulation.
Justification for classification or non-classification
According to CLP Regulation EC No. 1272/2008 and based on the studies of skin and eye irritation, it is concluded that the substance 2-chloro-p-phenylene diamine is ‘’not classified’’as skin and eye irritant.
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