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EC number: 203-266-8 | CAS number: 105-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral Toxicity:
The acute oral toxicity dose (LD50) for 1,4-Diethenylbenzene (CAS no.: 105-06-6) was considered based on data available for the structurally and functionally similar read across chemicals. The LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene can be classified as “Category 4” for acute oral toxicity.
Acute Inhalation Toxicity:
The acute inhalation toxicity dose (LC50) for 1,4-Diethenylbenzene (CAS no.: 105-06-6) was considered based on data available for the structurally and functionally similar read across chemicals. The LC50 value is >5 mg/L. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute inhalation toxicity.
Acute dermal Toxicity:
The acute dermal toxicity dose (LD50) for 1,4-Diethenylbenzene (CAS no.: 105-06-6) was considered based on data available for the structurally and functionally similar read across chemicals. The LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally and functionally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute oral toxicity studies as- WoE-2 and WoE-3Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - IUPAC Name: 1,4-diethenylbenzene- Mol. formula: C10H10- Molecular Weight: 130.189 g/mole- InChI: 1S/C10H10/c1-3-9-5-7-10(4-2)8-6-9/h3-8H,1-2H2- Smiles: C(c1ccc(cc1)C=C)=C- Physical state: solid
- Species:
- rat
- Strain:
- other: 1. CD rat 2. not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1. TEST ANIMALS- Age at study initiation: 4 week-old- Fasting period before study: fasted overnight2. not specified
- Route of administration:
- other: 1. oral: gavage 2. oral: unspecified
- Vehicle:
- other: 1. corn oil 2. unchanged (no vehicle)
- Details on oral exposure:
- 1. not specified2. not specified
- Doses:
- 1. 700, 1000, 1429, 2014 mg/kg2. 1600 mg/kg
- No. of animals per sex per dose:
- 1. groups of 5 rats of each sex2. Total = 10
- Control animals:
- not specified
- Details on study design:
- 1. - Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, survivors were killed and necropsied.- Other examinations performed: Animals were observed for mortality and clinical signs.2. - Duration of observation period following administration: 14 days- Other examinations performed: Animals were observed for mortality and body weight changes.
- Statistics:
- 1. not specified2. not specified
- Preliminary study:
- 1. not specified2. not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 732 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 503 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 027 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1. Mortality occurred within 3 days of administration.2. Mortality was observed with 1 day.
- Clinical signs:
- 1. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity.2. not specified
- Body weight:
- 1. not specified2. Body weight change was observed.
- Gross pathology:
- 1. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining.2. not specified
- Other findings:
- 1. not specified2. not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- According to CLP regulation, the test chemical 1,4-diethenylbenzene (CAS no.: 105-06-6) can be classified as "Category 4" for acute oral toxicity, as the LD50 value is between 300-2000 mg/kg bw.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute oral toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 700, 1000, 1429, 2014 mg/kg bw. The test chemical was dissolved incorn oil and administered via oral gavage route. Animals were observed for mortality and clinical signs for 14 days after administration of the test substance and survivors were killed and necropsied. Decedents were necropsied as soon as possible after death. Mortality occurred within 3 days of administration. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining. Hence, LD50 value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.
2. Acute oral toxicity study was conducted by using test chemical (Undiluted) in 10 male rats at the dose concentration of 1600 mg/kg. Animals were observed for mortality and body weight changes for 14 days. Mortality was observed with 1 day. Body weight change was observed. Therefore, LD50 value was considered to be 1600 mg/kg bw, when 10 male rats were treated with test chemical via oral route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 732 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally and functionally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute inhalation toxicity studies as- WoE-2 and WoE-3Acute Inhalation toxicity test was carried out to study the effects of the test chemicals on rodents
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - IUPAC Name: 1,4-diethenylbenzene- Mol. formula: C10H10- Molecular Weight: 130.189 g/mole- InChI: 1S/C10H10/c1-3-9-5-7-10(4-2)8-6-9/h3-8H,1-2H2- Smiles: C(c1ccc(cc1)C=C)=C- Physical state: solid
- Species:
- other: 1. rat 2. mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1. not specified2. not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- 1. not specified2. not specified
- Details on inhalation exposure:
- 1. not specified2. not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- 1. 7 h 2. 4 h
- Concentrations:
- 1. 645 ppm (645000 mg/m3)2. 54000 mg/m3
- No. of animals per sex per dose:
- 1. not specified2. not specified
- Control animals:
- not specified
- Details on study design:
- 1. - Other examinations performed: Animals were observed for mortality and clinical signs.2. not specified
- Statistics:
- 1. not specified2. not specified
- Preliminary study:
- 1. not specified2. not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 645 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 54 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 1. 50% mortality was observed at 645000 mg/m32. 50% mortality was observed at 54000 mg/m3
- Clinical signs:
- other: 1. Toxic effects were not observed.2. not specified
- Body weight:
- 1. not specified2. not specified
- Gross pathology:
- 1. not specified2. not specified
- Other findings:
- 1. not specified2. not specified
- Interpretation of results:
- other: Not classified
- Conclusions:
- According to CLP regulation, the test chemical 1,4-diethenylbenzene (CAS no.: 105-06-6) cannot be classified for acute inhalation toxicity, as the LC50 value is >5 mg/L.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the acute inhalation toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentration of 645 ppm by inhalation route via vapors for 7 hours. Animals were observed for mortality and clinical signs. 50% mortality was observed. Toxic effects were not observed. Hence, LC50 value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.
2. Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentrations of 54000 mg/m3 by inhalation route via vapors for 4 hours. 50% mortality was observed. Hence, LC50 value was considered to be 54000 mg/m3, when mice were exposed with test chemical via inhalation route by vapors for 4 hrs.
Thus, based on the above summarised studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LC50 value is >5 mg/L. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute inhalation toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 645 000 mg/m³
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally and functionally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute dermal toxicity studies as- WoE 2.and WoE 3. Acute dermal toxicity test was carried out to study the effects of the test chemicals on rodents
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - IUPAC Name: 1,4-diethenylbenzene- Mol. formula: C10H10- Molecular Weight: 130.189 g/mole- InChI: 1S/C10H10/c1-3-9-5-7-10(4-2)8-6-9/h3-8H,1-2H2- Smiles: C(c1ccc(cc1)C=C)=C- Physical state: solid
- Species:
- other: 1. rat 2. rabbit
- Strain:
- other: 1. CD rat 2. not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 1. not specified2. not specified
- Type of coverage:
- other: 1. occlusive 2. dermal
- Vehicle:
- other: 1. unchanged (no vehicle) 2. not specified
- Details on dermal exposure:
- 1. TEST SITE - Area of exposure: clipped skin - % coverage: The material was spread over a 5 x 5 cm area - Type of wrap if used: The material was covered with gauss and then an impermeable bandage. REMOVAL OF TEST SUBSTANCE - Washing (if done): The dressing was removed and the remaining material removed with a wet towel. - Time after start of exposure:24 hours 2. not specified
- Duration of exposure:
- 1. 24 hours 2. not specified
- Doses:
- 1. 2000 mg/kg2. 5000 mg/kg bw
- No. of animals per sex per dose:
- 1. groups of 5 rats of each sex2. Total = 4 rabbits
- Control animals:
- not specified
- Details on study design:
- 1. - Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, animals were sacrificed on the 14th day after removal of the test substance, and submitted to a necropsy for detection of possible macroscopic effects on the major organs.- Other examinations performed: Animals were observed for mortality, clinical signs and body weight changes.2. Details on study design:- Other examinations performed: Animals were observed for mortality and clinical signs
- Statistics:
- 1. not specified2. not specified
- Preliminary study:
- 1. not specified2. not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1. No mortality was observed at 2000 mg/kg bw.2. 1/4 animal died at 5000 mg/kg bw.
- Clinical signs:
- 1. No adverse clinical signs were reported and the application site was free of local irritation throughout the 14 day observation period. 2. No clinical signs were reported other than skin irritation which was graded as slight to moderate redness and moderate edema.
- Body weight:
- 1. Animals gained bodyweight normally.2. not specified
- Gross pathology:
- 1. All organs appeared normal on necropsy.2. not specified
- Other findings:
- 1. not specified2. not specified
- Interpretation of results:
- other: Not classified
- Conclusions:
- According to CLP regulation the test chemical 1,4-diethenylbenzene (CAS no.: 105-06-6) cannot be classified for acute dermal toxicity, as the LD50 value is >2000 mg/kg bw
- Executive summary:
Data available for the structurally similar read across chemicals has been reviewed to determine the acute dermal toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute dermal toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 2000 mg/kg bw. The material (neat) was spread over a 5 x 5 cm area of clipped skin and covered with gauss and then an impermeable bandage. The material was left on the skin for 24 hours after which the dressing was removed and the remaining material removed with a wet towel. Animals were observed for 14 days after removal of the dressing, were sacrificed on the 14thday after removal of the test substance, and submitted to a necropsy for detection of possible macroscopic effects on the major organs. No mortality was observed at 2000 mg/kg bw. No adverse clinical signs were reported and the application site was free of local irritation throughout the 14 day observation period. Animals gained bodyweight normally. All organs appeared normal on necropsy. Hence, LD50 value was considered to be >2000 mg/kg bw, when groups of 5 CD rats of each sex were treated with test chemical by dermal application occlusively.
2. Acute dermal toxicity study was conducted in 4 rabbits at the dose concentration of 5000 mg/kg bw by dermal application. Animals were observed for mortality and clinical signs. 1/4 animal died at 5000 mg/kg bw. No clinical signs were reported other than skin irritation which was graded as slight to moderate redness and moderate edema. Therefore, LD50 value was considered to be >5000 mg/kg bw, when 4 rabbits were treated with test chemical by dermal application.
Thus, based on the above summarised studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute dermal toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-reviewed journal.
Additional information
Acute oral Toxicity:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute oral toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 700, 1000, 1429, 2014 mg/kg bw. The test chemical was dissolved incorn oil and administered via oral gavage route. Animals were observed for mortality and clinical signs for 14 days after administration of the test substance and survivors were killed and necropsied. Decedents were necropsied as soon as possible after death. Mortality occurred within 3 days of administration. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining. Hence, LD50 value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.
2. Acute oral toxicity study was conducted by using test chemical (Undiluted) in 10 male rats at the dose concentration of 1600 mg/kg. Animals were observed for mortality and body weight changes for 14 days. Mortality was observed with 1 day. Body weight change was observed. Therefore, LD50 value was considered to be 1600 mg/kg bw, when 10 male rats were treated with test chemical via oral route.
Thus, based on the above summarised studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene can be classified as “Category 4” for acute oral toxicity.
Acute Inhalation Toxicity:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the acute inhalation toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentration of 645 ppm by inhalation route via vapors for 7 hours. Animals were observed for mortality and clinical signs. 50% mortality was observed. Toxic effects were not observed. Hence, LC50 value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.
2. Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentrations of 54000 mg/m3 by inhalation route via vapors for 4 hours. 50% mortality was observed. Hence, LC50 value was considered to be 54000 mg/m3, when mice were exposed with test chemical via inhalation route by vapors for 4 hrs.
Thus, based on the above summarised studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LC50 value is >5 mg/L. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute inhalation toxicity.
Acute dermal Toxicity:
Data available for the structurally similar read across chemicals has been reviewed to determine the acute dermal toxicity of the test chemical 1,4-Diethenylbenzene (CAS no.: 105-06-6). The studies are as mentioned below:
1. Acute dermal toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 2000 mg/kg bw. The material (neat) was spread over a 5 x 5 cm area of clipped skin and covered with gauss and then an impermeable bandage. The material was left on the skin for 24 hours after which the dressing was removed and the remaining material removed with a wet towel. Animals were observed for 14 days after removal of the dressing, were sacrificed on the 14thday after removal of the test substance, and submitted to a necropsy for detection of possible macroscopic effects on the major organs. No mortality was observed at 2000 mg/kg bw. No adverse clinical signs were reported and the application site was free of local irritation throughout the 14 day observation period. Animals gained bodyweight normally. All organs appeared normal on necropsy. Hence, LD50 value was considered to be >2000 mg/kg bw, when groups of 5 CD rats of each sex were treated with test chemical by dermal application occlusively.
2. Acute dermal toxicity study was conducted in 4 rabbits at the dose concentration of 5000 mg/kg bw by dermal application. Animals were observed for mortality and clinical signs. 1/4 animal died at 5000 mg/kg bw. No clinical signs were reported other than skin irritation which was graded as slight to moderate redness and moderate edema. Therefore, LD50 value was considered to be >5000 mg/kg bw, when 4 rabbits were treated with test chemical by dermal application.
Thus, based on the above summarised studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 1,4-Diethenylbenzene cannot be classified for acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies, 1,4-Diethenylbenzene (CAS no.: 105-06-6) and it’s structurally and functionally similar read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw for acute oral toxicity; LC50 value is >5 mg/L for acute inhalation toxicity and LD50 value is >2000 mg/kg bw, for acute dermal toxicity. Thus, comparing these values with the criteria of CLP regulation, 1,4-Diethenylbenzene can be classified as “Category 4” for acute oral toxicity and cannot be classified for acute dermal and inhalation toxicity.
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