Niobium pentachloride

Endpoint summary

Description of key information

For the target substance niobium pentachloride acute toxicity data is available for the oral route from two publications. Zhilova, 1966 published  LD50 values for the rat (1400 mg/kg bw) and mouse (829 mg/kg bw). Haley, 1962 determined the oral LD50 in male CF1 mice with 940 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Publication, which meets generally accepted scientifc standards

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

Study is an acute oral toxicity, but as the study is from 1966 no OECD guideline for acute oral toxicity was available at that time

GLP compliance:

no

Test type:

other: acute oral toxicity

Limit test:

no

Species:

mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no detailed information provided

Route of administration:

oral: unspecified

Vehicle:

other: vaseline oil

Details on oral exposure:

no data provided

Doses:

no data provided

No. of animals per sex per dose:

no data provided

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data

Statistics:

N.A.

Sex:

not specified

Dose descriptor:

LD50

Effect level:

829 mg/kg bw

Based on:

test mat.

Mortality:

Mortality occured, but no detailed information provided

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

In conclusion, the oral LD50 value in mice after treatment with niobium pentachloride was 829 mg/kg body weight.

Executive summary:

In an acute oral toxicity study mice were orally exposed to niobium pentachloride in vaseline oil. Animals were observed for 14 days. Based on the results, the oral LD50 was considered to be 829 mg/kg body weight.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

829 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Two publications are available, in which rodents were treated orally with niobium pentachloride (target substance). In the publication by Zhilova, 1966 rats and mice were administered orally with the target substance and were afterwards observed for a period of 14 days. Based on mortality, the LD50 was determined to be for the rat: 1400 mg/kg bw and for the mouse: 829 mg/kg bw.

Haley, 1962 determined in an acute oral toxicity study the LD50 in male mice with 940 mg/kg bw after treatment with niobium pentachloride.

Depending on species and vehicle, LD50 values vary between 829 mg/kg and 1400 mg/kg. All values are within the LD50 range of 300 – 2000 mg/kg for acute oral toxicity category 4 according to CLP.

Justification for selection of acute toxicity – oral endpoint
Publication, which meets generally accepted scientific standards

Justification for classification or non-classification

Based on the available data, niobium pentachloride warrant classification for acute oral toxicity Category 4 (H302) in accordance to regulation (EC) No 1272/2008.