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EC number: 205-503-0 | CAS number: 141-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- Study predates introduction of GLP and OECD guidelines, but follows acceptable scientific methods.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study carried out before introduction of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Malonic acid
- EC Number:
- 205-503-0
- EC Name:
- Malonic acid
- Cas Number:
- 141-82-2
- Molecular formula:
- C3H4O4
- IUPAC Name:
- propanedioic acid
- Test material form:
- solid: crystalline
- Details on test material:
- Batch No: 20160723Purity: 99.5 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Fasted albino rats weighing 200-300 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The product under test was placed in a glass syringe and introduced through the esophagus into the stomach with a stainless steel catheter.
- Doses:
- 6 dose groups (males & females) + control group (males & females) with dosages of:- 1 000 mg/kg - 2 000 mg/kg- 2 500 mg/kg- 3 200 mg/kg- 4 000 mg/kg- 8 000 mg/kg
- No. of animals per sex per dose:
- 5 per sex per dose5 per sex per control group
- Control animals:
- yes
- Details on study design:
- A group of approximately 70 albino male and female rats, fasted for twenty-four hours were employed to establish an LD50 range for each product under test.Young adult rats which had not been used for previous test purposes were assigned to various dose levels at random. Both sexes were equally distributed.The product under test was placed in a glass syringe and introduced through the esophagus into the stomach with a stainless steel catheter.Animals on the same dosage level were then placed in a common cage with free access to food and water. The animals were observed daily for atwo week period. No postmortem, or histopathology examinations were performed in this particular study
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No preliminary study performed.
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 2 630 - < 4 000
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 8 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 750 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 2 280 - < 3 390
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD100
- Effect level:
- 4 000 mg/kg bw
- Mortality:
- No mortality was observed at dose concentrations of 4000 mg/kg in males. Animals were found dead at 8000 mg/kg on day 4 and above (>8000 -32000 mg/kg) in male rats.No mortality was observed at dose concentrations of 4000 - 10000 mg/kg in females. Animals were found dead at 12500 mg/kg and above (>12500 -32000 mg/kg) in female rats.Details are given in the table below.
- Clinical signs:
- other: Male rats: unkempt coats were noted for 36-48 hours at 4000 mg/kg. At levels of 8000 mg/kg, 10000 mg/kg and 12500 mg/kg, lethargy was accompanied with spasmodic movements, nasal hemorrhage and unkempt coats. Survivors appeared normal by the ninth day.The
- Gross pathology:
- No Postmortem, or histopathology examinations were performed in this particular study.
- Other findings:
- No other findings
Any other information on results incl. tables
Mortality:
Dose Level (mg/kg) | No. of deaths (males) | Number of deaths (females) |
1000 | 0 | 0 |
2000 | 0 | 1 (at day 2) |
2500 | 1 (at day 1) | 2 (at day 1) |
3200 | 2 (at day 1) | 3 (at day 1) |
4000 | 4 (3 at day 1; 1 at day 2) | 5 (at day 1) |
8000 | 5 (at day 1) | 5 (at day 1) |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 for malonic acid in male albino rats is 3250 mg/kg bw and for female albino rats 2750 mg/kg bw in the acute toxicity study.
- Executive summary:
In an oral acute toxicity study, the LD50 for malonic acid in male albino rats was 3250 mg/kg bw and for female albino rats 2750 mg/kg bw.
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