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Diss Factsheets
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EC number: 249-942-6 | CAS number: 29901-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No experimental data about skin or respiratory sensitisation by test material are available. But there are several data from study reports, public journals and other literature sources which describe and characterize sulfanilic acid as well as the sodium salt.It is acceptable to derive sensitising properties from experimental data of sulfanilic acid and the sodium analogue. The potassium salt as well as the sodium salt dissociates in aqueous solution in free sulfanilic acid and the respective ions.
In several tests in guinea pig and mouse, sulfanilic acid is described to be sensitising to skin. It is assumed that N-acetylation of sulfanilic acid leads to an immune reaction and, therefore, to IgE-formation. Thus, also the test substance is considered to be sensitising and classified with R43, Xi.
Migrated from Short description of key information:
In several tests in guinea pig and mouse, sulfanilic acid is described to be sensitising to skin. It is assumed that N-acetylation of sulfanilic acid leads to an immune reaction and, therefore, to IgE-formation. Thus, also the test substance is considered to be sensitising and classified with R43, Xi.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies for read across substances are considered reliable and suitable for classification purposes under 67/548/EEC. It was shown that the read across substances cause sensitisation of the skin. As a result the substance is considered to be classified for skin sensitization under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data for read across substances are reliable and suitable for classification purposes under Regulation 1272/2008. It was shown that the read across substances cause sensitisation of the skin. As a result the substance is considered to be classified for skin sensitization under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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