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Diss Factsheets
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EC number: 219-210-0 | CAS number: 2387-03-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from BASF study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- 14 days study investigated for determine the acute toxicity of the test substance Lumogen LT light yellow to rat by intraperitoneal route.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- EC Number:
- 219-210-0
- EC Name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- Cas Number:
- 2387-03-3
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report):Lumogen LT light yellow- Molecular formula (if other than submission substance):C22H16N202- Molecular weight (if other than submission substance):340,385g/mol- Smiles notation (if other than submission substance):Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance):1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Substance type:Organic- Physical state:Solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE- Concentration in vehicle: 15% suspention- Amount of vehicle (if gavage): 0.5% aqueous solution
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: No data- Necropsy of survivors performed:NO
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 100 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- Yellow colored feces observed
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Conclusions:
- LD50 value for test substance Lumogen LT light yellow by intraperitoneal route was found to be >3100 mg/kg.
- Executive summary:
During 14 days acute toxicity study 15% suspension of test substance Lumogen LT light yellow in 0.5% vehicle CMC (carboxymethyl cellulose) was given intraperitoneally to mouse.
LD50 value for test substance Lumogen LT light yellow by intraperitoneal route was found to be >3100mg/kg.
Based on the result of the experiment it is concluded that test substance Lumogen LT light yellow was non toxic by intraperitoneal route according to CLP criteria.
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